| Linagliptin 5 mg | Glimepiride 1–4 mg | Placebo | |||
---|---|---|---|---|---|---|
n = 39* | n = 41†| n = 39* | ||||
Baseline | Unadjusted change from baseline at day 28 | Baseline | Unadjusted change from baseline at day 28 | Baseline | Unadjusted change from baseline at day 28 | |
Plasma glucose fasting (mg/dL) | 135.8 (3.7) | −14.4 (2.4) | 134.5 (3.1) | −29.8 (3.6) | 137.1 (4.2) | −1.9 (2.0) |
Plasma glucose 2-h postprandial (mg/dL) | 179.8 (5.5) | −19.7 (4.9) | 178.7 (5.9) | −37.3 (4.7) | 183.3 (6.8) | 0.2 (3.5) |
Triglycerides fasting (mmol/L) | 1.61 (0.10) | −0.26 (0.08) | 1.64 (0.09) | −0.23 (0.10) | 1.81 (0.24) | 0.07 (0.10) |
Triglycerides 2-h postprandial (mmol/L) | 1.78 (0.12) | −0.32 (0.06) | 1.81 (0.10) | −0.21 (0.08) | 1.95 (0.18) | 0.02 (0.07) |
LDL-cholesterol fasting (mmol/L) | 2.80 (0.13) | 0.00 (0.06) | 2.92 (0.13) | 0.04 (0.06) | 2.80 (0.13) | 0.00 (0.06) |
LDL-cholesterol 2-h postprandial (mmol/L) | 2.63 (0.12) | 0.01 (0.05) | 2.76 (0.12) | 0.03 (0.06) | 2.64 (0.13) | 0.02 (0.05) |
HDL-cholesterol fasting (mmol/L) | 1.20 (0.06) | 0.01 (0.02) | 1.20 (0.06) | 0.03 (0.02) | 1.20 (0.06) | 0.00 (0.02) |
HDL-cholesterol 2-h postprandial (mmol/L) | 1.13 (0.06) | 0.02 (0.02) | 1.13 (0.05) | 0.03 (0.02) | 1.15 (0.05) | 0.01 (0.01) |
Day SBP (mmHg) | 136.9 (1.9) | −0.1 (0.9) | 136.0 (2.1) | 1.9 (0.9) | 135.7 (2.1) | 0.2 (1.2) |
Night SBP (mmHg) | 124.5 (2.1) | −0.8 (1.2) | 126.2 (2.0) | −0.2 (1.1) | 124.5 (2.0) | −0.1 (1.3) |
24-h SBP (mmHg) | 134.3 (1.8) | −0.3 (0.9) | 134.1 (2.0) | 1.5 (0.9) | 133.2 (2.0) | 0.1 (1.1) |
Day DBP (mmHg) | 81.7 (1.3) | 0.3 (0.5) | 81.0 (1.4) | 0.4 (0.6) | 80.8 (1.5) | 0.3 (0.6) |
Night DBP (mmHg) | 71.9 (1.4) | −0.7 (0.8) | 73.3 (1.5) | −0.2 (0.6) | 72.4 (1.4) | −0.4 (0.7) |
24-h DBP (mmHg) | 79.7 (1.3) | 0.1 (0.5) | 79.5 (1.4) | 0.2 (0.5) | 79.1 (1.5) | 0.1 (0.6) |
Day heart rate (bpm) | 78.5 (1.6) | 2.7 (1.1) | 77.8 (1.6) | 1.8 (0.8) | 77.4 (1.7) | 0.5 (0.9) |
Night heart rate (bpm) | 68.9 (1.6) | 2.0 (0.9) | 69.1 (1.6) | 1.9 (0.8) | 69.3 (1.5) | 0.4 (0.7) |
24-h heart rate (bpm) | 76.5 (1.6) | 2.4 (1.0) | 76.0 (1.6) | 1.7 (0.7) | 75.9 (1.6) | 0.4 (0.8) |