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Table 2 Cardiovascular risk factor levels at baseline and after 28 days (efficacy set)

From: A randomised, active- and placebo-controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes

 

Linagliptin 5 mg

Glimepiride 1–4 mg

Placebo

n = 39*

n = 41†

n = 39*

Baseline

Unadjusted change from baseline at day 28

Baseline

Unadjusted change from baseline at day 28

Baseline

Unadjusted change from baseline at day 28

Plasma glucose fasting (mg/dL)

135.8 (3.7)

−14.4 (2.4)

134.5 (3.1)

−29.8 (3.6)

137.1 (4.2)

−1.9 (2.0)

Plasma glucose 2-h postprandial (mg/dL)

179.8 (5.5)

−19.7 (4.9)

178.7 (5.9)

−37.3 (4.7)

183.3 (6.8)

0.2 (3.5)

Triglycerides fasting (mmol/L)

1.61 (0.10)

−0.26 (0.08)

1.64 (0.09)

−0.23 (0.10)

1.81 (0.24)

0.07 (0.10)

Triglycerides 2-h postprandial (mmol/L)

1.78 (0.12)

−0.32 (0.06)

1.81 (0.10)

−0.21 (0.08)

1.95 (0.18)

0.02 (0.07)

LDL-cholesterol fasting (mmol/L)

2.80 (0.13)

0.00 (0.06)

2.92 (0.13)

0.04 (0.06)

2.80 (0.13)

0.00 (0.06)

LDL-cholesterol 2-h postprandial (mmol/L)

2.63 (0.12)

0.01 (0.05)

2.76 (0.12)

0.03 (0.06)

2.64 (0.13)

0.02 (0.05)

HDL-cholesterol fasting (mmol/L)

1.20 (0.06)

0.01 (0.02)

1.20 (0.06)

0.03 (0.02)

1.20 (0.06)

0.00 (0.02)

HDL-cholesterol 2-h postprandial (mmol/L)

1.13 (0.06)

0.02 (0.02)

1.13 (0.05)

0.03 (0.02)

1.15 (0.05)

0.01 (0.01)

Day SBP (mmHg)

136.9 (1.9)

−0.1 (0.9)

136.0 (2.1)

1.9 (0.9)

135.7 (2.1)

0.2 (1.2)

Night SBP (mmHg)

124.5 (2.1)

−0.8 (1.2)

126.2 (2.0)

−0.2 (1.1)

124.5 (2.0)

−0.1 (1.3)

24-h SBP (mmHg)

134.3 (1.8)

−0.3 (0.9)

134.1 (2.0)

1.5 (0.9)

133.2 (2.0)

0.1 (1.1)

Day DBP (mmHg)

81.7 (1.3)

0.3 (0.5)

81.0 (1.4)

0.4 (0.6)

80.8 (1.5)

0.3 (0.6)

Night DBP (mmHg)

71.9 (1.4)

−0.7 (0.8)

73.3 (1.5)

−0.2 (0.6)

72.4 (1.4)

−0.4 (0.7)

24-h DBP (mmHg)

79.7 (1.3)

0.1 (0.5)

79.5 (1.4)

0.2 (0.5)

79.1 (1.5)

0.1 (0.6)

Day heart rate (bpm)

78.5 (1.6)

2.7 (1.1)

77.8 (1.6)

1.8 (0.8)

77.4 (1.7)

0.5 (0.9)

Night heart rate (bpm)

68.9 (1.6)

2.0 (0.9)

69.1 (1.6)

1.9 (0.8)

69.3 (1.5)

0.4 (0.7)

24-h heart rate (bpm)

76.5 (1.6)

2.4 (1.0)

76.0 (1.6)

1.7 (0.7)

75.9 (1.6)

0.4 (0.8)

  1. Data are mean (standard error)
  2. DBP diastolic blood pressure, HDL high-density lipoprotein, LDL low-density lipoprotein, SBP systolic blood pressure, Day 07:00 to 23:00 h; night 23:00 to 07:00 h
  3. * Some values at baseline are based on n = 40
  4. † Some values at day 28 are based on n = 40