Skip to main content

Table 4 Correlation between the changes of LDL-C subspecies, HDL-C subspecies and the changes of lipid parameters

From: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin

  Dapagliflozin Sitagliptin
ΔLDL-C (mg/dL) Δsd LDL-C (mg/dL) Δlb LDL-C (mg/dL) ΔLDL-C (mg/dL) Δsd LDL-C (mg/dL) Δlb LDL-C (mg/dL)
r p r p r p r p r p r p
ΔTG (mg/dL) 0.085 0.604 0.008 0.959 0.055 0.736 0.125 0.430 0.155 0.345 −0.009 0.953
ΔLDL-C (mg/dL)    0.080 0.625 0.665 <0.001*    0.425 0.006* 0.507 0.001*
Δsd LDL-C (mg/dL) 0.080 0.625    −0.690 <0.001* 0.425 0.006*    −0.324 0.043*
Δlb LDL-C (mg/dL) 0.665 <0.001* −0.690 <0.001*    0.507 0.001* −0.324 0.043*   
Δapo AI (mg/dL) 0.320 0.046* 0.280 0.084 0.022 0.890 0.301 0.073 0.044 0.795 0.013 0.938
Δapo AII (mg/dL) 0.466 0.002* 0.270 0.095 0.135 0.410 0.584 <0.001* 0.241 0.150 0.198 0.238
Δapo B (mg/dL) 0.894 <0.001* 0.078 0.639 0.592 <0.001* 0.909 <0.001* 0.467 0.003* 0.377 0.021*
Δapo CIII (mg/dL) 0.316 0.049 0.247 0.128 0.044 0.787 0.287 0.084 0.451 0.005* −0.135 0.422
  ΔHDL-C (mg/dL) ΔHDL2-C (mg/dL) ΔHDL3-C (mg/dL) ΔHDL-C (mg/dL) ΔHDL2-C (mg/dL) ΔHDL3-C (mg/dL)
r p r p r p r p r p r p
ΔTG (mg/dL) −0.156 0.341 −0.125 0.446 −0.069 0.674 −0.176 0.277 −0.074 0.646 −0.228 0.155
ΔLDL-C (mg/dL) 0.295 0.067 0.167 0.306 0.239 0.142 0.555 <0.001* 0.254 0.113 0.307 0.053
Δsd LDL-C (mg/dL) 0.183 0.262 −0.066 0.688 0.411 0.009* 0.192 0.240 −0.036 0.825 0.392 0.013*
Δlb LDL-C (mg/dL) 0.760 0.641 0.171 0.297 −0.134 0.413 0.288 0.071 0.561 <0.001* 0.307 0.053
Δapo AI (mg/dL) 0.890 <0.001* 0.697 <0.001* 0.450 0.004* 0.808 <0.001* 0.516 0.002* 0.489 0.003*
Δapo AII (mg/dL) 0.647 <0.001* 0.394 0.012* 0.500 0.001* 0.633 <0.001* 0.354 0.034* 0.446 0.007*
ΔapoB (mg/dL) 0.283 0.080 0.240 0.141 0.105 0.522 0.368 0.019* 0.135 0.406 0.230 0.153
ΔapoCIII (mg/dL) 0.309 0.055 0.234 0.149 0.156 0.340 0.132 0.415 0.026 0.871 0.100 0.538
  1. r coefficient of correlation, TG triglycerides, LDL-C low-density lipoprotein-cholesterol, sd LDL-C small dense LDL-cholesterol, lb LDL-C large buoyant LDL-cholesterol, Apo apolipoprotein, HDL-C high-density lipoprotein-cholesterol, HDL2-C high-density lipoprotein 2-cholesterol, HDL3-C high-density lipoprotein 3-cholesterol
  2. * p < 0.05