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Table 3 Correlation between the changes of LDL-C subspecies, HDL-C subspecies and the changes of clinical parameters

From: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin

  Dapagliflozin Sitagliptin
ΔLDL-C (mg/dL) Δsd LDL-C (mg/dL) Δlb LDL-C (mg/dL) ΔLDL-C (mg/dL) Δsd LDL-C (mg/dL) Δlb LDL-C (mg/dL)
r p r p r p r p r p r p
ΔBW (kg) 0.042 0.795 −0.191 0.241 0.174 0.287 0.088 0.588 −0.084 0.607 0.017 0.917
ΔHbA1c (%) 0.109 0.506 −0.118 0.472 0.168 0.305 0.217 0.190 −0.025 0.088 0.280 0.087
ΔC-peptide (ng/mL) 0.208 0.229 0.130 0.455 0.055 0.750 0.516 0.023* −0.133 0.586 0.648 0.002*
ΔAST (IU/L) 0.008 0.957 −0.019 0.906 −0.019 0.906 0.188 0.388 0.286 0.195 −0.138 0.527
ΔALT (IU/L) 0.038 0.816 0.167 0.308 −0.097 0.555 0.026 0.906 0.232 0.297 −0.210 0.334
ΔγGTP (IU/L) 0.220 0.176 0.186 0.256 0.020 0.900 0.291 0.177 0.465 0.029* −0.267 0.217
  ΔHDL-C (mg/dL) ΔHDL2-C (mg/dL) ΔHDL3-C (mg/dL) ΔHDL-C (mg/dL) ΔHDL2-C (mg/dL) ΔHDL3-C (mg/dL)
r p r p r p r p r p r p
ΔBW (kg) −0.189 0.247 −0.208 0.203 0.002 0.986 0.107 0.509 −0.098 0.545 −0.221 0.169
ΔHbA1c (%) −0.046 0.780 −0.073 0.656 0.036 0.826 0.263 0.109 0.329 0.043* 0.148 0.378
ΔC-peptide (ng/mL) −0.074 0.671 −0.165 0.342 0.127 0.463 0.095 0.698 0.255 0.291 −0.300 0.211
ΔAST (IU/L) 0.220 0.178 0.220 0.177 0.029 0.860 −0.394 0.062 −0.347 0.104 0.072 0.742
ΔALT (IU/L) 0.164 0.316 0.168 0.306 0.017 0.915 −0.289 0.180 −0.263 0.225 0.052 0.810
ΔγGTP (IU/L) 0.197 0.227 0.153 0.350 0.095 0.563 0.201 0.570 −0.180 0.395 0.222 0.308
  1. r coefficient of correlation, BW body weight, AST aspartate aminotransferase, ALT alanine aminotransferase, γGTP γ-glutamyltranspeptidase, LDL-C low-density lipoprotein-cholesterol, sd LDL-C small dense LDL-cholesterol, lb LDL-C large buoyant LDL-cholesterol, HDL-C high-density lipoprotein-cholesterol, HDL2-C high-density lipoprotein 2-cholesterol, HDL3-C high-density lipoprotein 3-cholesterol
  2. * p < 0.05