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Table 1 Clinical parameters before and after administration of dapagliflozin or sitagliptin

From: Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin

 

Dapagliflozin (n = 40)

Sitagliptin (n = 40)

p valueb

Pre treatment

Post treatment

% change

p valuea

Pre treatment

Post treatment

% change

p valuea

BW (kg)

78.4 ± 14.3

76.2 ± 1.8

−2.8

<0.001*

77.6 ± 11.6

77.7 ± 11.6

0.1

0.089

0.042*

SBP (mmHg)

130.7 ± 15.8

126.5 ± 12.7

−3.2

0.022*

133.2 ± 17.8

131.0 ± 13.3

−1.7

0.611

0.031*

DBP (mmHg)

86.9 ± 10.7

82.3 ± 16.0

−5.3

0.188

88.1 ± 9.5

84.4 ± 11.0

−4.2

0.024*

0.242

HR (bpm)

82.5 ± 10.4

81.6 ± 13.9

−1.1

0.300

81.5 ± 10.3

77.1 ± 10.8

−5.4

0.056

0.344

Hb (mg/dL)

14.4 ± 1.2

15.1 ± 1.4

4.9

<0.001*

14.2. ± 1.4

14.5 ± 1.5

2.1

0.088

<0.001*

Ht (%)

41.9 ± 3.5

44.5 ± 4.0

6.2

<0.001*

41.4 ± 4.3

41.9 ± 4.2

1.2

0.297

<0.001*

AST (IU/L)

34.5 ± 19.4

26.8 ± 12.8

−22.3

<0.001*

33.2 ± 9.8

35.4 ± 14.9

6.6

0.089

<0.001*

ALT (IU/L)

46.6 ± 37.0

33.5 ± 24.9

−28.1

<0.001*

42.8 ± 15.0

44.9 ± 18.4

4.9

0.202

<0.001*

γGTP (IU/L)

53.2 ± 43.0

42.3 ± 47.2

−20.5

0.109

50.9 ± 18.1

52.2 ± 22.0

2.6

0.729

0.107

BUN (mg/dL)

14.6 ± 4.3

16.8 ± 5.0

15.1

<0.001*

13.5 ± 4.5

15.3 ± 4.6

13.3

0.115

0.367

Cre (mg/dL)

0.72 ± 0.17

0.74 ± 0.23

2.8

0.173

0.77 ± 0.17

0.81 ± 0.18

5.2

0.110

0.757

eGFR (mL/min/1.73 m2)

86.2 ± 18.4

83.6 ± 23.2

−3.0

0.230

83.5 ± 22.7

79.2 ± 21.4

−5.1

0.003*

0.545

FPG (mg/dL)

145.8 ± 47.8

122.3 ± 24.9

−16.1

0.002*

144.9 ± 57.9

126.2 ± 43.9

−12.9

0.043*

0.673

HbA1c (%)

7.61 ± 1.15

6.86 ± 0.81

−9.9

<0.001*

7.55 ± 1.64

6.92 ± 1.20

−8.3

0.006*

0.378

C-peptide (ng/mL)

2.79 ± 1.39

2.40 ± 1.56

−14.0

0.018*

2.70 ± 1.25

2.78 ± 1.48

3.0

0.633

0.190

Adiponectin (ng/mL)

6.0 ± 3.4

7.6 ± 4.2

26.7

<0.001*

6.2 ± 5.3

6.2 ± 3.8

0

0.899

0.002*

  1. Data are expressed as mean ± standard deviation or percent changes after the treatment
  2. BW body weight, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, Hb hemoglobin, Ht hematocrit, AST aspartate aminotransferase, ALT alanine aminotransferase, γGTP γ-glutamyltranspeptidase, BUN blood urea nitrogen, Cre creatinine, eGFR estimated glomerular filtration rate, FPG fasting plasma glucose
  3. ap values for the intragroup comparison (pre vs. post treatment values in dapagliflozin or sitagliptin group, * p < 0.05)
  4. bp values for intergroup comparison (dapagliflozin vs. sitagliptin group in the changes from pre to post treatment, * p < 0.05)