| Dapagliflozin (n = 40) | Sitagliptin (n = 40) | p valueb | ||||||
---|---|---|---|---|---|---|---|---|---|
Pre treatment | Post treatment | % change | p valuea | Pre treatment | Post treatment | % change | p valuea | ||
BW (kg) | 78.4 ± 14.3 | 76.2 ± 1.8 | −2.8 | <0.001* | 77.6 ± 11.6 | 77.7 ± 11.6 | 0.1 | 0.089 | 0.042* |
SBP (mmHg) | 130.7 ± 15.8 | 126.5 ± 12.7 | −3.2 | 0.022* | 133.2 ± 17.8 | 131.0 ± 13.3 | −1.7 | 0.611 | 0.031* |
DBP (mmHg) | 86.9 ± 10.7 | 82.3 ± 16.0 | −5.3 | 0.188 | 88.1 ± 9.5 | 84.4 ± 11.0 | −4.2 | 0.024* | 0.242 |
HR (bpm) | 82.5 ± 10.4 | 81.6 ± 13.9 | −1.1 | 0.300 | 81.5 ± 10.3 | 77.1 ± 10.8 | −5.4 | 0.056 | 0.344 |
Hb (mg/dL) | 14.4 ± 1.2 | 15.1 ± 1.4 | 4.9 | <0.001* | 14.2. ± 1.4 | 14.5 ± 1.5 | 2.1 | 0.088 | <0.001* |
Ht (%) | 41.9 ± 3.5 | 44.5 ± 4.0 | 6.2 | <0.001* | 41.4 ± 4.3 | 41.9 ± 4.2 | 1.2 | 0.297 | <0.001* |
AST (IU/L) | 34.5 ± 19.4 | 26.8 ± 12.8 | −22.3 | <0.001* | 33.2 ± 9.8 | 35.4 ± 14.9 | 6.6 | 0.089 | <0.001* |
ALT (IU/L) | 46.6 ± 37.0 | 33.5 ± 24.9 | −28.1 | <0.001* | 42.8 ± 15.0 | 44.9 ± 18.4 | 4.9 | 0.202 | <0.001* |
γGTP (IU/L) | 53.2 ± 43.0 | 42.3 ± 47.2 | −20.5 | 0.109 | 50.9 ± 18.1 | 52.2 ± 22.0 | 2.6 | 0.729 | 0.107 |
BUN (mg/dL) | 14.6 ± 4.3 | 16.8 ± 5.0 | 15.1 | <0.001* | 13.5 ± 4.5 | 15.3 ± 4.6 | 13.3 | 0.115 | 0.367 |
Cre (mg/dL) | 0.72 ± 0.17 | 0.74 ± 0.23 | 2.8 | 0.173 | 0.77 ± 0.17 | 0.81 ± 0.18 | 5.2 | 0.110 | 0.757 |
eGFR (mL/min/1.73 m2) | 86.2 ± 18.4 | 83.6 ± 23.2 | −3.0 | 0.230 | 83.5 ± 22.7 | 79.2 ± 21.4 | −5.1 | 0.003* | 0.545 |
FPG (mg/dL) | 145.8 ± 47.8 | 122.3 ± 24.9 | −16.1 | 0.002* | 144.9 ± 57.9 | 126.2 ± 43.9 | −12.9 | 0.043* | 0.673 |
HbA1c (%) | 7.61 ± 1.15 | 6.86 ± 0.81 | −9.9 | <0.001* | 7.55 ± 1.64 | 6.92 ± 1.20 | −8.3 | 0.006* | 0.378 |
C-peptide (ng/mL) | 2.79 ± 1.39 | 2.40 ± 1.56 | −14.0 | 0.018* | 2.70 ± 1.25 | 2.78 ± 1.48 | 3.0 | 0.633 | 0.190 |
Adiponectin (ng/mL) | 6.0 ± 3.4 | 7.6 ± 4.2 | 26.7 | <0.001* | 6.2 ± 5.3 | 6.2 ± 3.8 | 0 | 0.899 | 0.002* |