Fig. 3
From: T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity
T-cad deficiency induced-endothelial dysfunction was exacerbated in T2DM. Concentration-dependent vasorelaxation of aortic vascular rings subjected to a high glucose/high fat treatment (high glucose: 25.5 m mol/l; high fat/palmitate: 300 μ mol/l) and b high fat diet alone for 8 weeks. Top representative figures; Bottom analysis result. Each mouse aorta generated 2–3 rings, n = 6–7 rings/group. WT Wild type litternates, T-cad KO T-cadherin knockout mice. **P < 0.01 vs. WT