MicroRNA | Expression in cardiovascular disease | Direct target(s) | Pathophysiological effect(s) | Reference(s) |
---|---|---|---|---|
MiR-1 | Downregulated | JCN, Fbln2 | Cardiac hypertrophy, remodelling, arrhythmias, cardiomyocyte apoptosis | |
MiR-133 | Downregulated | CTGF, Bim, Bmf, Caspase-9 | Cardiac remodelling, cardiomyocyte apoptosis | |
MiR-499 | Downregulated | Pdcd4, Pacs2, Dyrk2 | Cardiomyocyte apoptosis | [210] |
MiR-222 | Downregulated | Hmbox-1, HIPK-1, HIPK-2, p27, p57 | Cardiomyocyte apoptosis, cellular senescence, coronary artery disease, atherosclerosis | |
MiR-126 | Downregulated | SPRED1, PIK3R2 | Coronary artery disease, atherosclerosis, endothelial cell apoptosis |