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Table 3 Age and gender standardized rates of ischemic stroke among Korean adults according to the presence or absence of diabetes (2006–2013)

From: Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)

Variables

Year

Change

P value

2006–2007

2008–2009

2010–2011

2012–2013

Absolute change

Percent change

Linear trend

Ischemic stroke

 Overall population

  No. of events/10,000 in diabetes

188.94

157.29

135.46

119.07

−69.87

−36.98

<.0001

  95% CI

186.41–191.46

155.28–159.29

133.75–137.18

117.51–120.63

   

  No. of events/10,000 in non-diabetes

64.72

58.25

51.29

46.00

−18.72

−28.92

<.0001

  95% CI

64.66–64.78

58.21–58.30

51.25–51.33

45.96–46.03

   

  RR (95% CI)

2.92 (2.88–2.96)

2.70 (2.66–2.74)

2.64 (2.60–2.68)

2.59 (2.55–2.63)

  

<.0001

 Men

  No. of events/10,000 in diabetes

188.65

159.79

141.53

125.13

−63.52

−33.67

<.0001

  95% CI

184.30–193.00

156.42–163.16

138.67–144.39

122.68–127.58

   

  No. of events/10,000 in non-diabetes

63.64

57.35

51.63

46.93

−16.71

−26.26

<.0001

  95% CI

63.52–63.75

57.25–57.44

51.55–51.70

46.86–46.99

   

  RR (95% CI)

2.96 (2.92–3.01)

2.79 (2.75–2.83)

2.74 (2.7–2.78)

2.67 (2.63–2.7)

  

<.0001

 Women

  No. of events/10,000 in diabetes

189.2

154.96

129.82

113.43

−75.77

−40.05

<.0001

  95% CI

183.56–194.84

150.39–159.52

125.90–133.73

109.74–117.12

   

  No. of events/10,000 in non-diabetes

65.73

59.1

50.98

45.13

−20.60

−31.34

<.0001

  95% CI

65.62–65.85

59.01–59.19

50.91–51.05

45.07–45.19

   

  RR (95% CI)

2.88 (2.84–2.92)

2.62 (2.59–2.66)

2.55 (2.51–2.58)

2.51 (2.48–2.55)

  

<.0001

 Aged < 65 years

  No. of events/10,000 in diabetes

104.76

91.84

82.45

75

−29.76

−28.41

<.0001

  95% CI

101.91–107.61

89.24–94.43

80.20–84.71

72.91–77.09

   

  No. of events/10,000 in non-diabetes

22.98

21.07

19.66

18.12

−4.86

−21.15

<.0001

  95% CI

22.96–23.00

21.05–21.09

19.64–19.67

18.10–18.13

   

  RR (95% CI)

4.56 (4.48–4.64)

4.36 (4.28–4.44)

4.19 (4.12–4.27)

4.14 (4.07–4.21)

  

<.0001

 Aged ≥ 65 years

  No. of events/10,000 in diabetes

653.11

523.37

433.24

368.51

−284.6

−43.58

<.0001

  95% CI

595.24–710.98

490.38–556.36

412.47–454.00

354.72–382.30

   

  No. of events/10,000 in non-diabetes

315.28

291.7

253.99

228.35

−86.93

−27.57

<.0001

  95% CI

312.09–318.47

288.99–294.41

251.83–256.15

226.62–230.08

   

  RR (95% CI)

2.07 (2.05–2.1)

1.79 (1.77–1.82)

1.71 (1.68–1.73)

1.61 (1.59–1.63)

  

<.0001

  1. In the whole analysis, P values for interaction between diabetes status and years was less than .0001 by regression models