Table 1 Demographic, clinical, echocardiographic and cardiovascular MRI measurements
Healthy volunteers | ObT2D | HV/ObT2D | |
|---|---|---|---|
(n = 19) | (n = 20) | p value | |
A. subject characteristics | |||
Age (years) | 47.5 ± 12.5 | 54.6 ± 7.8 | |
Women (%) | 45 | 40.0 | |
HbA1c (%) | – | 8.5 ± 1.0 | |
Duration of diabetes (years) | – | 11.3 ± 6.1 | |
Proportion of patients taking lipid-lowering therapy (%) | – | 100.0 | |
Proportion of patients taking anti-hypertensives (%) | – | 80.0 | |
History of CVD (%) | – | 30.0 | |
Body surface area (m2) | 1.9 ± 0.2 | 2.2 ± 0.2 | ** |
Body mass index (kg/m2) | 24.8 ± 2.6 | 39.7 ± 5.8 | *** |
B. echocardiographic parameters in ObT2D patients | |||
Age (years) | 54.6 ± 7.8 | 40–60 | |
Mitral peak E velocity (m/s) | 0.75 ± 0.24 | 0.75 ± 0.17 | |
Mitral peak A velocity (m/s) | 0.74 ± 0.18 | 0.62 ± 0.15 | |
E/A ratio | 0.99 ± 0.28 | 1.24 ± 0.39 | |
E′ Lateral myocardium velocity (cm/s) | 10.50 ± 2.4 | 12.5 ± 3.0 | |
E/E′ ratio | 7.6 ± 3.7 | 6.3 ± 2.2 | |
Aortic valve peak velocity (m/s) | 1.43 ± 0.57 | ||
C. MRI LV function parameters | |||
Indexed LV mass (g/m2) | 75.1 ± 14.9 | 80.8 ± 16.1 | |
LV EDV (mL) | 122.8 ± 24.0 | 130.8 ± 34.0 | |
LV ESV (mL) | 49.4 ± 13.4 | 44.8 ± 18.6 | |
Indexed LV EDV (mL/m2) | 63.8 ± 11.4 | 58.9 ± 13.4 | |
Indexed LV ESV (mL/m2) | 25.7 ± 7.1 | 20.1 ± 7.3 | * |
LV EF (%) | 60.9 ± 7.4 | 66.1 ± 8.8 | |
Mean Mid. LV thickness (mm) | 11.1 ± 2.0 | 12.9 ± 1.6 | ** |