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Table 1 Characterization of an experimental model of atherosclerosis

From: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

 

8 weeks

12 weeks

18 weeks

24 weeks

Control (n = 5)

ApoE−/− (n = 5)

Control (n = 8)

ApoE−/− (n = 8)

Control (n = 8)

ApoE−/− (n = 8)

Control (n = 8)

ApoE−/− (n = 8)

Body weight (g)

20.4 ± 0.1

21.3 ± 0.6

24.7 ± 0.5

24.3 ± 0.5

27.7 ± 1

26.5 ± 0.3

28.3 ± 1

30.5 ± 1

BAT (mg)/BW (g)

3.9 ± 0.02

2.8 ± 0.6

4.3 ± 0.4

3.7 ± 0.4

4.1 ± 0.7

3.0 ± 0.1

4.7 ± 0.5

3.4 ± 0.5

WAT (mg)/BW (g)

10.5 ± 0.8

11 ± 0.6

12.2 ± 2.7

17 ± 0.2

14.7 ± 2

17.5 ± 1

22 ± 4

27 ± 1

Glucose (mg/dL)

80.5 ± 6.5

79 ± 13

83 ± 4

104 ± 15

110.9 ± 12

106 ± 4

117 ± 1

101 ± 11

Insulin (ng/mL)

0.24 ± 0.003

0.3 ± 0.1

0.25 ± 0.02

0.32 ± 0.02

0.26 ± 0.02

0.35 ± 0.04

0.24 ± 0.02

0.3 ± 0.01

Cholesterol (mg/dL)

79.1 ± 13

461 ± 39*

109.4 ± 8.4*

565.3 ± 48.8*

122.05 ± 12*

569.8 ± 18*

120 ± 5*

603.9 ± 31**

TG (mg/dL)

43.4 ± 1.6

53.9 ± 25*

36.6 ± 5

56.9 ± 8*

62.3 ± 12

73.2 ± 5*

57.2 ± 8

110 ± 12**

  1. Male ApoE−/− mice were fed with Western type diet since 6 week of age for 2 weeks (control and ApoE−/− at 8 weeks of age), 6 weeks (control and ApoE−/− at 12 weeks of age), 12 weeks (control and ApoE−/− at 18 weeks of age) or 18 weeks (control and ApoE−/− at 24 weeks of age). We measured the body weight, BAT (mg)/BW (g), WAT (mg)/BW (g), glucose, insulin, cholesterol and triglycerides plasma levels the same day of sacrifice in fasted mice. ApoE−/− mice at all weeks of age showed hypercholesterolemia and hypertriglyceridemia and the other parameters with no significant differences in relation to each their controls
  2. BW body weight, BAT brown adipose tissue, WAT white adipose tissue, TG triglycerides
  3. * p < 0.05, ** p < 0.005 vs. each control
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Cardiovascular Diabetology

ISSN: 1475-2840