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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

Fig. 6

VSMCs migrated into the intima of atherosclerotic plaques express IR or IGF-IR. a Representative photomicrographs (10× magnification) and quantifications of immunofluorescence of α-SMA in aortic roots from ApoE−/− mice at 8 and 24 weeks of age and their respective controls. b Representative photomicrographs (20× magnification) of double immunofluorescence against IR or IGF-IR (green staining) and α-SMA (red staining) in aortic roots from ApoE−/− mice at 24 weeks of age. DAPI staining was performed to localize nuclei of cells presented in aortic roots (blue staining). White arrows indicate VSMCs in the intima of fibrous plaque from 24-week-old ApoE−/− mice. AE ApoE−/− mice, C control mice. C 8ws (n = 5); AE 8ws (n = 5); AE 18ws (n = 8); C 24ws (n = 8); AE 24ws (n = 8)

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Cardiovascular Diabetology

ISSN: 1475-2840