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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

Fig. 4

Effect of IGF-IR inhibition on VSMC migration induced by insulin or IGFs. Quantification of PPP effect on VSMC migration stimulated with insulin (a), IGF-I (b) or IGF-II (c) at 12 h by wound healing closure. *p < 0.05 vs. each control; #p < 0.05, ##p < 0.005 vs. IRB VSMCs. d Formation of hybrid receptors (IRA/IGF-IR or IRB/IGF-IR) in IRLoxP+/+, IRA and IRB VSMCs stimulated with insulin, IGF-I or IGF-II. We performed the immunoprecipitation against IRβ followed by Western blot against IGF-IRβ. Experiments were performed at least 3 times. *p < 0.05, **p < 0.005, ***p < 0.001 vs. each control

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Cardiovascular Diabetology

ISSN: 1475-2840