Fig. 1

GRK2+/− animals show an attenuated obese and insulin-resistant phenotype after long-term HFD feeding. a Comparison of body weight evolution and body weight gain (the former analyzed by two-way ANOVA followed by Bonferroni post hoc test) between WT and GRK2+/− animals after 30 weeks of HFD feeding. b Daily food intake (statistical analysis: two-tailed unpaired T test). c, d Intraperitoneal insulin tolerance tests (ITT) in SD- and HFD-fed mice (statistical analysis: two-way ANOVA), and e histogram showing the product of ITTs area under the curve (AUC). Data in all panels are mean ± SEM with N = 6–7 per genotype and condition using unpaired two-tail Student’s t test analysis except where indicated. *P < 0.05, **P < 0.01, ***P < 0.001