Fig. 8
Effect of 7 weeks of empagliflozin treatment on circadian rhythm of LF-SBP (a), sBRG (b), and LF/HF ratio of PI (c) during 24 h (12-h dark period and 12-h light period) of SHRcp as estimated by telemetry system. Control SHRcp fed control diet; SGLT2, SHRcp fed control diet containing empagliflozin; UGE urinary glucose excretion; NS not significant. PI pulse interval. Values are mean ± SEM n = 5 in control, n = 6 in SGLT2. Statistical analysis was performed by two-factor ANOVA with repeated measures