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Table 2 The cross-lagged path coefficients with adjustment for covariates

From: Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study

 

Path coefficients

Goodness-of-fit model

β1

β2

P valuec

RMR

CFI

Model 1a

 TG ↔ Gutt index

−0.131 (−0.168 to −0.099)**

−0.047 (−0.072 to −0.010)*

<0.001

0.048

0.916

 HDL-C ↔ Gutt index

0.134 (0.103 to 0.167)**

0.023 (−0.012 to 0.057)

<0.001

0.021

0.970

 TG ↔ HOMA-IR

0.088 (0.055 to 0.121)**

0.086 (0.049 to 0.123)**

0.934

0.038

0.934

 HDL-C ↔ HOMA-IR

−0.092 (−0.119 to −0.061)**

−0.122 (−0.150 to −0.099)**

0.216

0.040

0.914

 TG ↔ HOMA-%β

−0.089 (−0.119 to −0.057)**

−0.084 (−0.109 to −0.060)**

0.837

0.058

0.895

 HDL ↔ HOMA-%β

0.089 (0.061 to 0.120)**

0.119 (0.096 to 0.151)**

0.216

0.039

0.941

 TG ↔ 2-h Insulin

0.125 (0.090 to 0.159)**

0.040 (0.010 to 0.068)*

<0.001

0.045

0.919

 HDL-C ↔ 2-h Insulin

−0.112 (−0.146 to −0.080)**

−0.026 (−0.056 to 0.010)

<0.001

0.041

0.987

Model 2b

 2-h insulin ↔ Gutt index

−0.121 (−0.162 to −0.081)**

−0.036 (−0.079 to 0.010)

<0.001

0.059

0.884

  1. Data are cross-lagged path coefficients and its 95% confidence interval with bootstrap simulation
  2. Covariates included age, gender, BMI, alcohol consumption, smoking, regular exercise and caloric intake
  3. TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; BMI, body mass index; RMR, root mean square residual; CFI, comparative fitness index
  4. Gutt index = [75,000 + (fasting glucose − 2-h glucose) × 0.19 × body weight]/(120 × log [(fasting insulin + 2-h insulin)/2] × [(fasting glucose + 2-h glucose)/2])
  5. aModel 1: β1 describes the path from the baseline TG/HDL-C to the follow-up Gutt index, HOMA-models or 2-h insulin, and β2 describes the path from the baseline Gutt index, HOMA-models or 2-h insulin to the follow-up TG/HDL-C
  6. bModel 2: β1 describes the path from the baseline 2-h insulin to the follow-up Gutt index, and β2 describes the path from the baseline Gutt index to the follow-up 2-h insulin
  7. c P value for the difference between β1 and β2
  8. * P < 0.05 for β1 and β2 being different from 0, ** P < 0.01 for β1 and β2 being different from 0
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Cardiovascular Diabetology

ISSN: 1475-2840