Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study

Table 1 Linear regression analysis of baseline blood lipids with follow-up IR-related indices

Baseline variable predictors	Follow-up dependent variables	Univariate model^a			Multiple model^b
Baseline variable predictors	Follow-up dependent variables	β	Std β	P	β	Std β	P
Ln (TCHO)	Ln (Gutt index)	−0.083	−0.038	0.017	−0.022	−0.010	0.536
	Ln (HOMA-IR)	0.520	0.079	<0.001	0.221	0.031	0.086
	Ln (HOMA-%β)	−0.313	−0.050	0.005	−0.216	−0.030	0.080
	Ln (2-h insulin)	0.079	0.020	0.233	−0.055	−0.014	0.423
Ln (TG)	Ln (Gutt index)	−0.098	−0.131	<0.001	−0.094	−0.125	<0.001
	Ln (HOMA-IR)	0.342	0.154	<0.001	0.294	0.132	<0.001
	Ln (HOMA-%β)	0.345	0.156	<0.001	−0.298	0.135	<0.001
	Ln (2-h insulin)	0.174	0.129	<0.001	0.173	0.129	<0.001
Ln (HDL-C)	Ln (Gutt index)	0.073	0.126	<0.001	0.072	0.124	<0.001
	Ln (HOMA-IR)	−0.215	0.122	<0.001	−0.201	−0.114	<0.001
	Ln (HOMA-%β)	0.212	0.121	<0.001	0.198	0.113	<0.001
	Ln (2-h insulin)	−0.114	−0.109	<0.001	−0.108	−0.104	<0.001
Ln (LDL-C)	Ln (Gutt index)	−0.010	−0.010	0.658	–	–	–
	Ln (HOMA-IR)	0.037	0.013	0.467	–	–	–
	Ln (HOMA-%β)	−0.084	−0.030	0.092	–	–	–
	Ln (2-h insulin)	−0.027	−0.015	0.366	–	–	–

β, regression coefficient; Std β, standard regression coefficient; TCHO, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BMI, body mass index
Gutt index = [75,000 + (fasting glucose − 2-h glucose) × 0.19 × body weight]/(120 × log [(fasting insulin + 2-h insulin)/2] × [(fasting glucose + 2-h glucose)/2])
^aEach regression model includes a single baseline blood lipid plus age, gender, smoking, alcohol consumption, regular exercise, caloric intake, BMI and dependent variable at baseline
^bRegression model includes TCHO, TG and HDL-C plus age, gender, smoking, alcohol consumption, regular exercise, caloric intake, BMI and dependent variables at baseline

ISSN: 1475-2840