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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study

Fig. 2

Mediating effects of follow-up 2-h insulin on the association between baseline TG/HDL-C and follow-up Gutt-index. Mediation analysis was used with adjustment for age, gender, BMI, alcohol consumption, smoking, regular exercise and caloric intake. Data are standard regression coefficients and 95% CI. Effect different from 0: **P < 0.01. BMI, body mass index; TG, triglycerides; HDL-C, high-density lipoprotein cholesterol; CI, confidence interval; Gutt index = [75,000 + (fasting glucose − 2-h glucose) × 0.19 × body weight]/(120 × log [(fasting insulin + 2-h insulin)/2] × [(fasting glucose + 2-h glucose)/2])

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