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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus

Fig. 5

a Effect of TMN355 on cell viability was measured using MTT assay in a time and dose dependent manner. TMN 355 concentrations of 0.5, 1, 2.5, 5 and 10 μM were tested at 3, 6 and 9 h. b Effect of TMN 355 on protein level expression of cyclophilin A. Protein densities of immunoreactive bands measured by the Quantity One 1D analysis software program. Data are presented as mean ± SD (n = 3) and asterisk represents p < 0.05. c mRNA level of cyclophilin A in the presence and absence of TMN 355 after treatment with oxidized LDL. d Confocal microscopy images of Dil OXLDL uptake in THP differentiated macrophages after treatment with TMN 355 for 6 h. Mean intensity was quantified using microscope imaging software NIS-Elements Viewer, *p < 0.05 was considered significant

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