Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease

Table 2 Independent all-cause mortality risk predictors in patients with stable CAD using the (a) NCEP and (b) IDF MetS definition

	Adjusted HR	95% CI for upper	P value
(a) Hazard ration among the NCEP metabolic group
Metabolic NCEP	1.21	1.14–1.29	<0.001
Age >65 years	1.08	1.07–1.08	<0.001
Male gender	1.19	1.09–1.31	<0.001
Creatinine >1.5 mg/dL	1.59	1.38–1.84	<0.001
Diabetes mellitus	1.61	1.49–1.74	<0.001
Hypertension	1.08	1.01–1.15	0.01
Past MI	1.41	1.31–1.52	<0.001
Previous CVA	1.07	0.83–1.39	0.59
NYHA >2	1.25	1.10–1.43	<0.001
Active smoker	1.57	1.43–1.71	<0.001
(b) Hazard ration among the IDF metabolic group
Metabolic IDF	1.17	1.07–1.28	<0.001
Age >65 years	1.08	1.08–1.09	<0.001
Male gender	1.17	1.06–1.29	<0.001
Creatinine >1.5 mg/dL	1.60	1.38–1.84	<0.001
Diabetes mellitus	1.68	1.56–1.81	<0.001
Hypertension	1.10	1.04–1.18	0.003
Past MI	1.41	1.31–1.52	<0.001
Previous CVA	1.10	0.85–1.42	0.48
NYHA >2	1.23	1.07–1.41	0.003
Active smoker	1.57	1.43–1.72	<0.001

Both models further adjusted for: hypertension, smoking status, and severe heart failure (NYHA >2)
CI 95% confidence interval; CVA cerebral-vascular accident; HR hazard ratio; MI myocardial infarction; NCEP National Cholesterol Education Program; IDF International Diabetes Federation; NYHA New York Heart Association

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