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Table 1 Baseline characteristics of the study population by the two metabolic syndrome definitions

From: Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease

 

Metabolic IDF definition

P value

Metabolic NCEP definition

P value

No (n = 13,291)

Yes (n = 2122)

No (n = 7967)

Yes (n = 7446)

Age (years)a

60 ± 7

59 ± 7

<0.001

60 ± 7

60 ± 7

0.29

Male gender

10,910 (82%)

1540 (73%)

<0.001

6600 (83%)

5850 (78%)

<0.001

Active smoker

1485 (11%)

276 (13%)

<0.001

832 (47%)

929 (53%)

<0.001

HTN

4197 (32%)

948 (45%)

<0.001

2197 (27%)

2948 (40%)

<0.001

DM

2355 (18%)

604 (29%)

<0.001

784 (10%)

2175 (30%)

<0.001

COPD

382 (3%)

70 (3%)

0.27

238 (3%)

214 (3%)

0.85

Past MI

9611 (72%)

1519 (72%)

0.91

5754 (72%)

5376 (72%)

0.92

Past CVA

236 (1.8%)

33 (1.6%)

0.47

131 (1.6%)

138 (1.9%)

0.26

NYHA class >2

753 (5%)

185 (9%)

<0.001

409 (5%)

491 (6.8%)

<0.001

Laboratory values (mg/dL)

 Creata

1.15 ± 0.2

1.11 ± 0.2

<0.001

1.15 ± 0.2

1.14 ± 0.2

0.02

 CHOa

224 ± 39

228 ± 42

<0.001

212 ± 37

228 ± 41

<0.001

 LDLa

155 ± 34

155 ± 37

0.73

154 ± 33

156 ± 36

<0.001

Medication

 Bezafibrate

1369 (10%)

193 (9%)

0.10

784 (10%)

778 (10%)

0.22

 Placebo

1347 (10%)

210 (10%)

0.68

760 (9.5%)

797 (11%)

0.02

 Beta-blockers

4527 (34%)

873 (41%)

<0.001

2484 (31%)

2916 (39%)

<0.001

 Nitrates

6568 (49%)

1150 (54%)

<0.001

3856 (48%)

3861 (51%)

<0.01

 CCB

6555 (49%)

1160 (54%)

<0.001

3904 (49%)

3810 (51%)

<0.01

 Diuretics

1926 (14%)

449 (21%)

<0.001

1018 (13%)

1356 (18%)

<0.001

 Anti-platelets agents

7934 (59%)

1136 (53%)

<0.001

4867 (61%)

4203 (56%)

<0.001

Components of the metabolic syndrome

 FPG >100 mg/dL

5805 (44%)

1412 (67%)

<0.001

1873 (23%)

5347 (72%)

<0.001

 Low HDLb

9155 (73%)

1858 (90%)

<0.001

4065 (56%)

6948 (94%)

<0.001

 TG >150 mg/dL

5226 (40%)

1297 (61%)

<0.001

1198 (15%)

5325 (72%)

<0.001

 BMI >30 kg/m2

340 (2.6%)

2122 (100%)

<0.001

340 (4%)

2122 (28%)

<0.001

 Elevated BPc

8978 (68%)

1761 (83%)

<0.001

4329 (54%)

6410 (86%)

<0.001

  1. BMI body mass index; BP blood pressure; CHO total cholesterol; COPD chronic obstructive pulmonary disease; Creat creatinine; CVA cerebral vascular accident; DM diabetes mellitus; FPG fasting plasma glucose; HDL high-density lipoprotein; HTN hypertension; IDF International Diabetes Federation; LDL low density lipoprotein; MI myocardial infarction; NCEP National Cholesterol Educational Program; NYHA New York Heart Association; TG triglycerides
  2. aContinuous variables are reported as mean ± standard deviation if normally distributed; otherwise, as median with 25th–75th range. Categorical variables are reported as numbers (%)
  3. bLow HDL defined as HDL <40 mg/dL in males and HDL <50 mg/dL in females
  4. cSystolic blood-pressure >130 mmHg or/and diastolic blood-pressure >85 mmHg