Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Gomez-Sanchez, Leticia; Garcia-Ortiz, Luis; Patino-Alonso, M. Carmen; Recio-Rodriguez, Jose I.; Fernando, Rigo; Marti, Ruth; Agudo-Conde, Cristina; Rodriguez-Sanchez, Emiliano; Maderuelo-Fernandez, Jose A.; Ramos, Rafel; Gomez-Marcos, Manuel A.

doi:10.1186/s12933-016-0465-7

Cardiovascular Diabetology

Table 3 Associations of MetS components with baPWV and CAVI values global and by gender

From: Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Components MS	Global (n = 2351)			Males subjects (n = 1450)			Females subjects (n = 901)
Components MS	β (95 % CI)	R²	p value	β (95 % CI)	R²	p value	β (95 % CI)	R²	p value
Dependent variable: baPWV
SBP, (mmHg)	0.062 (0.056 to 0.066)	0.371	<0.001	0.061 (0.055 to 0.067)	0.352	<0.001	0.061 (0.053 to 0.069)	0.397	<0.001
DBP, (mmHg)	0.082 (0.072 to 0.090)	0.299	<0.001	0.077 (0.066 to 0.089)	0.281	<0.001	0.085 (0.071 to 0.100)	0.329	<0.001
HDL-C, (mg/dl)	0.007 (−0.001 to 0.015)	0.206	0.075	0.012 (0.002 to 0.023)	0.196	0.003	0.012 (−0.008 to 0.014)	0.233	0.561
TGC, (mg/dl)	0.002 (0.001 to 0.003)	0.209	0.001	0.002 (0.001 to 0.003)	0.198	0.002	0.001 (−0.001 to 0.003)	0.234	0.182
FPG, (mg/dl)	0.007 (0.004 to 0.010)	0.210	<0.001	0.005 (0.001 to 0.009)	0.198	0.031	0.010 (0.005 to 0.015)	0.244	0.001
WC, (cm)	−0.004 (−0.012 to 0.004)	0.200	0.315	−0.002 (−0.014 to 0.009)	0.185	0.679	−0.007 (−0.019 to 0.005)	0.226	0.269
Dependent variable: CAVI
SBP, (mmHg)	0.015 (0.013 to 0.017)	0.398	<0.001	0.016 (0.013 to 0.018)	0.430	<0.001	0.014 (0.011 to 0.018)	0.327	<0.001
DBP, (mmHg)	0.020 (0.017 to 0.024)	0.377	<0.001	0.022 (0.017 to 0.026)	0.414	<0.001	0.017 (0.011 to 0.024)	0.302	<0.001
HDL-C, (mg/dl)	−0.001 (−0.004 to 0.002)	0.348	0.578	0.002 (−0.003 to 0.006)	0.382	0.486	−0.002 (−0.007 to 0.002)	0.282	0.301
TGC, (mg/dl)	0.001 (0.001 to 0.001)	0.351	0.002	0.001 (0.001 to 0.001)	0.286	0.002	0.001 (0.001 to 0.001)	0.382	0.289
FPG, (mg/dl)	0.003 (0.002 to 0.005)	0.355	<0.001	0.003 (0.001 to 0.005)	0.387	0.002	0.004 (0.002 to 0.006)	0.289	0.001
WC, (cm)	−0.013 (−0.016 to −0.009)	0.290	<0.001	−0.017 (−0.021 to −0.012)	0.354	<0.001	−0.017 (−0.023 to −0.012)	0.236	<0.001

Multiple linear regression models were used to analyze the associations of components of MetS to baPWV and CAVI values, globally and stratified by gender. Age, height, weight, antihypertensive drugs, lipid-lowering drugs and antidiabetic drugs were adjusted in the regression models. The exception was WC, which was adjusted for age and drug use because of collinearity problems
MetS metabolic syndrome; baPWV brachial-ankle pulse wave velocity; CAVI cardio-ankle vascular index; CI confidence interval; R ² Coefficient of determination; SBP systolic blood pressure; DBP diastolic blood pressure; HDL-C high density lipoprotein cholesterol; TGC triglycerides; FPG fasting plasma glucose; WC waist circumference

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com