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Table 3 Age- and gender- adjusted partial correlations coefficients between Ln-betrathrophin and metabolic parameters stratified by vitamin D status

From: Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Variables All (n = 559) Vitamin D > 15 ng/ml (n = 250) Vitamin D ≤ 15 ng/ml (n = 309)
r P r P r P
Obesity traits
BMI (kg/m2) 0.033 0.435 0.024 0.708 0.044 0.442
WC (cm) 0.014 0.736 −0.034 0.593 0.064 0.270
Percent body fat −0.004 0.917 −0.012 0.856 0.002 0.978
Pressures (mmHg)
SBP 0.026 0.537 −0.119 0.063 0.163** 0.004
DBP 0.075 0.079 −0.041 0.519 0.186** 0.001
Lipids (mmol/l)
TC 0.155*** <0.001 0.048 0.456 0.271*** <0.001
TGa 0.096* 0.024 −0.001 0.993 0.170** 0.003
LDL-C 0.134** 0.002 0.018 0.780 0.247*** <0.001
HDL-C 0.022 0.611 0.076 0.236 −0.013 0.818
Glucose and insulin-related traits
Glucose0 (mmol/l) 0.041 0.331 0.048 0.456 0.036 0.531
Glucose30 (mmol/l) 0.070 0.109 0.018 0.786 0.107 0.067
Glucose120 (mmol/l) 0.074 0.090 −0.044 0.504 0.140* 0.016
HbA1c (%) 0.119** 0.005 0.074 0.246 0.161** 0.005
Insulin0 (mU/L)a −0.025 0.551 −0.145* 0.023 0.079 0.173
Insulin30 (mU/L)a −0.043 0.321 −0.097 0.138 0.003 0.953
Insulin120 (mU/L)a −0.058 0.183 −0.153* 0.019 0.040 0.498
HOMA-IRa −0.016 0.709 −0.133* 0.038 0.084 0.144
ISI M a 0.040 0.360 0.154* 0.019 −0.063 0.287
IGIa −0.083 0.060 −0.092 0.165 −0.077 0.192
DIOa −0.059 0.183 0.019 0.773 −0.133* 0.025
Hepatic and renal-related traits
AST (IU/L)a 0.040 0.345 0.068 0.289 0.020 0.723
ALT (IU/L)a 0.043 0.317 0.009 0.894 0.087 0.131
Creatinine (mg/dL)a 0.228*** <0.001 0.144* 0.024 0.319*** <0.001
Uric acid (mg/dL)a 0.136** 0.001 0.118 0.065 0.165** 0.004
Adipokines
FGF21 (pg/ml)a 0.004 0.933 −0.063 0.336 0.058 0.324
Adiponectin (μg/mL)a 0.086* 0.044 0.039 0.545 0.142* 0.013
Vitamin D (ng/ml)a −0.196*** <0.001 −0.069 0.306 −0.265*** <0.001
  1. Values in italics are significant at P < 0.05
  2. BMI body mass index; WC waist circumference; SBP Systolic blood pressure; DBP Diastolic blood pressure; TC total cholesterol; TG triglycerides; LDL-C low density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; HOMA-IR homeostasis model assessment for insulin resistance; ISI M insulin sensitivity Matsuda index; IGI insulinogenesis index; DIO oral disposition index; AST Aspartate transaminase; ALT Alanine aminotransferase; FGF21 fibroblast growth factor 21
  3. aSkewed distributions were natural logarithmically transformed. Vitamin D was adjusting for visiting season. r: Partial Correlation Coefficients
  4. P ≤ 0.05
  5. ** P ≤ 0.01
  6. *** P ≤ 0.001