Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Junling Fu; Cong Hou; Lujiao Li; Dan Feng; Ge Li; Mingyao Li; Changhong Li; Shan Gao; Ming Li

doi:10.1186/s12933-016-0461-y

Cardiovascular Diabetology

Table 3 Age- and gender- adjusted partial correlations coefficients between Ln-betrathrophin and metabolic parameters stratified by vitamin D status

From: Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome

Variables	All (n = 559)		Vitamin D > 15 ng/ml (n = 250)		Vitamin D ≤ 15 ng/ml (n = 309)
Variables	r	P	r	P	r	P
Obesity traits
BMI (kg/m²)	0.033	0.435	0.024	0.708	0.044	0.442
WC (cm)	0.014	0.736	−0.034	0.593	0.064	0.270
Percent body fat	−0.004	0.917	−0.012	0.856	0.002	0.978
Pressures (mmHg)
SBP	0.026	0.537	−0.119	0.063	0.163**	0.004
DBP	0.075	0.079	−0.041	0.519	0.186**	0.001
Lipids (mmol/l)
TC	0.155***	<0.001	0.048	0.456	0.271***	<0.001
TG^a	0.096*	0.024	−0.001	0.993	0.170**	0.003
LDL-C	0.134**	0.002	0.018	0.780	0.247***	<0.001
HDL-C	0.022	0.611	0.076	0.236	−0.013	0.818
Glucose and insulin-related traits
Glucose₀ (mmol/l)	0.041	0.331	0.048	0.456	0.036	0.531
Glucose₃₀ (mmol/l)	0.070	0.109	0.018	0.786	0.107	0.067
Glucose₁₂₀ (mmol/l)	0.074	0.090	−0.044	0.504	0.140*	0.016
HbA1c (%)	0.119**	0.005	0.074	0.246	0.161**	0.005
Insulin₀ (mU/L)^a	−0.025	0.551	−0.145*	0.023	0.079	0.173
Insulin₃₀ (mU/L)^a	−0.043	0.321	−0.097	0.138	0.003	0.953
Insulin₁₂₀ (mU/L)^a	−0.058	0.183	−0.153*	0.019	0.040	0.498
HOMA-IR^a	−0.016	0.709	−0.133*	0.038	0.084	0.144
ISI ^a_M	0.040	0.360	0.154*	0.019	−0.063	0.287
IGI^a	−0.083	0.060	−0.092	0.165	−0.077	0.192
DIO^a	−0.059	0.183	0.019	0.773	−0.133*	0.025
Hepatic and renal-related traits
AST (IU/L)^a	0.040	0.345	0.068	0.289	0.020	0.723
ALT (IU/L)^a	0.043	0.317	0.009	0.894	0.087	0.131
Creatinine (mg/dL)^a	0.228***	<0.001	0.144*	0.024	0.319***	<0.001
Uric acid (mg/dL)^a	0.136**	0.001	0.118	0.065	0.165**	0.004
Adipokines
FGF21 (pg/ml)^a	0.004	0.933	−0.063	0.336	0.058	0.324
Adiponectin (μg/mL)^a	0.086*	0.044	0.039	0.545	0.142*	0.013
Vitamin D (ng/ml)^a	−0.196***	<0.001	−0.069	0.306	−0.265***	<0.001

Values in italics are significant at P < 0.05
BMI body mass index; WC waist circumference; SBP Systolic blood pressure; DBP Diastolic blood pressure; TC total cholesterol; TG triglycerides; LDL-C low density lipoprotein cholesterol; HDL-C high-density lipoprotein cholesterol; HOMA-IR homeostasis model assessment for insulin resistance; ISI _M insulin sensitivity Matsuda index; IGI insulinogenesis index; DIO oral disposition index; AST Aspartate transaminase; ALT Alanine aminotransferase; FGF21 fibroblast growth factor 21
^aSkewed distributions were natural logarithmically transformed. Vitamin D was adjusting for visiting season. r: Partial Correlation Coefficients
* P ≤ 0.05
** P ≤ 0.01
*** P ≤ 0.001

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