The effect of perioperative insulin treatment on cardiodepression in mild adiposity in mice

Table 3 Myocardial function and perfusion parameters in WD-fed mice compared to controls

	Control	WD-fed	p value
Fractional shortening (%)	56 ± 8	43 ± 6	<0.0001*
End-systolic elastance (E_es; mmHg/μL)	4.1 ± 2.4	2.0 ± 0.5	0.01*
Arterial elastance (E_a; afterload; mmHg/μL)	1.6 ± 0.4	1.8 ± 0.9	0.51
Ventriculo-arterial coupling (E_es/E_a ratio)	2.5 ± 1.4	1.3 ± 0.6	0.003*
Beta (diastolic stiffness; mmHg/μL)	0.04 ± 0.01	0.07 ± 0.03*	0.02*
Myocardial perfusion
Microvascular flow velocity β (sec⁻¹)	0.49 ± 0.20	0.59 ± 0.30	0.24
Microvascular blood volume A (A.U.)	0.014 ± 0.006	0.008 ± 0.005*	0.006*
Estimate of myocardial perfusion (A × β)	0.007 ± 0.005	0.004 ± 0.003*	0.03*

Data are presented as mean ± SD and n = 6–12 per group. Student t test, * p < 0.05

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