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Table 2 Relationships between skin autofluorescence and impaired eGFR (<60 mL/min/1.73 m2) after 4 years of follow-up in subjects with type 1 diabetes

From: Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study

  Univariate analysis OR (CI 95 %) p Multivariate analysis OR (CI 95 %) with adjustment for history of impaired eGFR <60 ml: N = 186 p
SAF 4.60 (2.11–10.00) <0.0001 7.42 (1.59–34.65) 0.01
Age 1.05 (1.02–1.09) 0.002 1.03 (0.96–1.09) 0.43
Sex 0.94 (0.40–2.20) 0.89 1.06 (0.21–5.33) 0.95
BMIa 1.13 (1.02–1.25) 0.016 1.18 (0.99–1.41) 0.06
Arterial hypertension 4.56 (1.74–11.95) 0.002 6.29 (0.86–46.11) 0.07
Duration of diabetes 1.04 (1.01–1.07) 0.013 1.01 (0.95–1.07) 0.78
HbA1ca 0.86 (0.53–1.39) 0.55 0.80 (0.41–1.58) 0.52
Tobaccoa 0.61 (0.20–1.88) 0.39 0.91 (0.15–5.40) 0.92
Albumin excretion rate ≥30 mg/24 ha 7.30 (2.87–18.57) <0.0001 3.14 (0.56–17.61) 0.19
eGFR <60 ml/min/1.73 m2 at baselinea 55.93 (18.17–172.18) 0.035 48.04 (8.84–261.07) <0.0001
History of MVE at baseline 3.37 (1.09–10.42) <0.0001 0.40 (0.06–2.90) 0.37
  1. aMissing data: BMI (n = 10); HbA1c (n = 1); tobacco (n = 13); albumin excretion rate (n = 6); eGFR (n = 7); EpiCKD (n = 30)