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Table 1 Relationships between skin autofluorescence and macrovascular events after 4 years of follow-up in subjects with type 1 diabetes

From: Skin autofluorescence predicts cardio-renal outcome in type 1 diabetes: a longitudinal study

  Univariate analysis OR (CI 95 %) p Multivariate analysis OR (CI 95 %) with adjustment for history of MVE: N = 214 p Multivariate analysis OR (CI 95 %) without adjustment for history of MVE: N = 214 p
SAF 3.22 (1.45–7.13) 0.004 2.98 (0.77–11.47) 0.11 4.84 (1.31–17.89) 0.02
Age 1.06 (1.02–1.10) 0.006 1.03 (0.97–1.09) 0.40 1.04 (0.98–1.10) 0.19
Sex 0.37 (0.10–1.37) 0.14 0.69 (0.11–4.26) 0.69 0.34 (0.07–1.78) 0.20
BMIa 1.13 (1.01–1.27) 0.036 1.18 (0.98–1.40) 0.08 1.13 (0.98–1.31) 0.10
Arterial hypertension 8.17 (1.79–37.32) 0.007 2.27 (0.35–14.74) 0.39 3.50 (0.65–18.94) 0.15
Duration of diabetes 1.05 (1.01–1.10) 0.007 1.00 (0.95–1.07) 0.88 1.02 (0.97–1.07) 0.49
HbA a1c 0.82 (0.46–1.47) 0.51 0.65 (0.23–1.81) 0.41 0.84 (0.40–1.77) 0.65
Tobaccoa 0.47 (0.10–2.14) 0.33 0.12 (0.01–1.32) 0.08 0.43 (0.07–2.60) 0.36
Albumin excretion rate ≥30 mg/24 ha 3.32 (1.04–10.53) 0.04 2.452 (0.40–15.07) 0.33 2.31 (0.47–11.32) 0.30
eGFR <60 mL/min/1.73 m2 at baselinea 1.68 (0.44–6.37) 0.45 0.14 (0.02–1.26) 0.08 0.27 (0.05–1.64) 0.16
MVE at baseline 25.68 (7.64–86.30) <0.0001 21.93 (3.85–124.81) 0.0005
  1. SAF skin autofluorescence; CKD chronic kidney disease; MVE macrovascular events
  2. aMissing data: BMI (n = 10); HbA1c (n = 1); Tobacco (n = 13); Albumin Excretion Rate (n = 6); eGFR (n = 7)