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Table 2 Crude and adjusted rate ratios for the risk of aortic aneurysm with oral antidiabetic drugs

From: Association between use of oral-antidiabetic drugs and the risk of aortic aneurysm: a nested case–control analysis

  No. (%) Odds ratio (95 % CI)
Cases (n = 4468) Control (n = 4468) Crude p value Adjusteda p value
No metformin useb 2882 2455 1 [Reference]   1 [Reference]  
Metformin use 1586 2013 0.64 (0.58–0.70) <0.001 0.72 (0.64–0.80) <0.001
No DPP-4 inhibitor useb 4305 4281 1 [Reference]   1 [Reference]  
DPP-4 use 163 187 0.85 (0.68–1.07) 0.168 1.07 (0.84–1.36) 0.582
No sulfonylurea useb 2779 2412 1 [Reference]   1 [Reference]  
Sulfonylurea use 1689 2056 0.68 (0.62–0.75) <0.001 0.82 (0.74–0.92) 0.001
No alpha-glucosidase inhibitors useb 4077 3999 1 [Reference]   1 [Reference]  
Alpha-glucosidase inhibitors use 391 469 0.81 (0.70–0.93) 0.004 0.95 (0.81–1.11) 0.507
No thiazolidinedione useb 4171 4065 1 [Reference]   1 [Reference]  
Thiazolidinedione use 297 403 0.70 (0.59–0.82) <0.001 0.82 (0.69–0.98) 0.003
  1. aAdjusted for using alpha blocker, ACE inhibitor or ARB, beta blocker, calcium channel blocker, diuretics, antiplatelet agent, warfarin, statin, steroid, antidepressants, NSAID, and insulin
  2. bUse of one prescription at any time prior to the index date