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Table 4 pD2 and Emax (%) values of insulin-induced relaxation in mesenteric arteries of control or HFD-fed mice incubated with vehicle, VO-OHpic, TNF-α or L-NAME

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Groups

pD2

Emax

Control

HFD

Control

HFD

C57Bl/6J

7.01 ± 0.15 (n = 5)

6.02 ± 0.18 (n = 6)*

80.8 ± 2.7 (n = 5)

52.8 ± 6.8 (n = 5)*

C57Bl/6J_YS-49

6.99 ± 0.19 (n = 5)

7.12 ± 0.10 (n = 6)#

91.8 ± 1.3 (n = 5)*

83.7 ± 2.0 (n = 5)#

C57Bl/6J_L-NAME

6.30 ± 0.14 (n = 6)*

–

47.4 ± 4.7 (n = 6)*

–

C57Bl/6J_TNF-α + VO-OHpic

7.29 ± 0.13 (n = 6)

–

63.5 ± 1.6 (n = 6)

–

C57Bl/6J_TNF-α + VO-OHpic + L-NAME

6.49 ± 0.23 (n = 6)&

–

33.5 ± 5.6 (n = 6)&

–

  1. Date represent the mean ± SEM of n experiments. Two-way ANOVA with Bonferroni post-test. * p < 0.05 vs. C57Bl/6J Control; # p < 0.05 vs. C57Bl/6J HFD; & p < 0.05 vs. C57Bl/6J_TNFα + VO-OHpic
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Cardiovascular Diabetology

ISSN: 1475-2840