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Table 3 pD2 and Emax (%) values of insulin-induced relaxation in mesenteric arteries of control or HFD-fed mice incubated with vehicle, VO-OHpic or TNF-α

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Groups pD2 Emax
Control HFD Control HFD
C57Bl/6J 7.01 ± 0.15 (n = 5) 6.02 ± 0.18 (n = 6)* 80.8 ± 2.7 (n = 5) 52.8 ± 6.8 (n = 5)*
C57Bl/6J_VO-OHpic 6.93 ± 0.22 (n = 5) 6.87 ± 0.11 (n = 7)# 86.9 ± 1.9 (n = 5) 78.0 ± 4.1 (n = 5)#
C57Bl/6J_TNF-α 6.30 ± 0.14 (n = 6)* 49.4 ± 2.7 (n = 6)
C57Bl/6J_TNF-α + VO-OHpic 7.29 ± 0.13 (n = 6)& 63.5 ± 1.6 (n = 6)*&
  1. Data represent the mean ± SEM of n experiments. Two-way ANOVA with Bonferroni post-test. * p < 0.05 vs. C57Bl/6J Control; # p < 0.05 vs. C57Bl/6J HFD; & p < 0.05 vs. C57Bl/6J_TNFα