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Table 3 pD2 and Emax (%) values of insulin-induced relaxation in mesenteric arteries of control or HFD-fed mice incubated with vehicle, VO-OHpic or TNF-α

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Groups

pD2

Emax

Control

HFD

Control

HFD

C57Bl/6J

7.01 ± 0.15 (n = 5)

6.02 ± 0.18 (n = 6)*

80.8 ± 2.7 (n = 5)

52.8 ± 6.8 (n = 5)*

C57Bl/6J_VO-OHpic

6.93 ± 0.22 (n = 5)

6.87 ± 0.11 (n = 7)#

86.9 ± 1.9 (n = 5)

78.0 ± 4.1 (n = 5)#

C57Bl/6J_TNF-α

6.30 ± 0.14 (n = 6)*

–

49.4 ± 2.7 (n = 6)

–

C57Bl/6J_TNF-α + VO-OHpic

7.29 ± 0.13 (n = 6)&

–

63.5 ± 1.6 (n = 6)*&

–

  1. Data represent the mean ± SEM of n experiments. Two-way ANOVA with Bonferroni post-test. * p < 0.05 vs. C57Bl/6J Control; # p < 0.05 vs. C57Bl/6J HFD; & p < 0.05 vs. C57Bl/6J_TNFα
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Cardiovascular Diabetology

ISSN: 1475-2840