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Table 2 pD2 and Emax (%) values of acetylcholine and insulin-induced relaxation in mesenteric arteries of control or HFD-fed mice incubated with vehicle or infliximab

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

Groups pD2 Emax
Control HFD Control HFD
C57Bl/6J (acetylcholine) 7.29 ± 0.06 (n = 6) 6.80 ± 0.04 (n = 6)* 92.8 ± 1.9 (n = 6) 59.9 ± 1.8 (n = 6)*
TNF-α−/− (acetylcholine) 7.16 ± 0.02 (n = 6) 6.94 ± 0.04 (n = 6)# 94.4 ± 2.1 (n = 6) 87.8 ± 1.3 (n = 6)#
C57Bl/6J (insulin) 7.01 ± 0.15 (n = 5) 6.02 ± 0.18 (n = 6)* 80.8 ± 2.7 (n = 5) 52.8 ± 6.8 (n = 5)*
TNF-α−/− (insulin) 6.84 ± 0.51 (n = 5) 6.91 ± 0.20 (n = 6)# 84.4 ± 2.1 (n = 5) 86.7 ± 2.9 (n = 5)#
C57Bl/6J_Infliximab 7.03 ± 0.14 (n = 5) 6.69 ± 0.21 (n = 6)# 85.0 ± 1.8 (n = 5) 63.7 ± 2.2 (n = 5)*
  1. Data represent the mean ± SEM of n experiments. Two-way ANOVA with Bonferroni post-test. * p < 0.05 vs. C57Bl/6J Control; # p < 0.05 vs. C57Bl/6J HFD
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Cardiovascular Diabetology

ISSN: 1475-2840