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Table 1 Characteristics of C57Bl/6J and TNF-α receptors deficient mice fed with control and high fat diets

From: TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice

  Control diet Control diet High fat diet High fat diet
C57Bl/6J TNF-α KO C57Bl/6J TNF-α KO
Initial body mass (g) 20.9 ± 0.5 20.6 ± 0.3 21.7 ± 0.4 21.2 ± 0.4
Final body mass (g) 28.8 ± 0.6 26.6 ± 0.6 42.5 ± 0.8* 40.9 ± 0.9*
Caloric intake (kcal/week) 74.8 ± 0.5 74.2 ± 0.5 91.4 ± 1.0* 94.8 ± 0.8*
Weight gain (g) 7.9 ± 0.4 5.9 ± 0.3 20.8 ± 0.9* 18.8 ± 1.1*
Feed efficiency (g/kcal) ×100 0.3 ± 0.04 0.2 ± 0.04 0.8 ± 0.08* 0.8 ± 0.03*
Epididymal fat (g) 0.50 ± 0.02 0.47 ± 0.03 4.41 ± 0.07* 4.13 ± 0.07*
Visceral fat (g) 0.15 ± 0.02 0.12 ± 0.02 2.85 ± 0.03* 2.77 ± 0.04*
Retroperitoneal fat (g) 0.14 ± 0.07 0.15 ± 0.03 2.99 ± 0.03* 1.78 ± 0.04*
Total fat (g) 0.79 ± 0.05 0.77 ± 0.09 10.25 ± 0.11* 8.72 ± 0.21*
Adiposity index (%) 2.24 ± 0.1 1.77 ± 0.2 13.27 ± 0.6* 12.25 ± 0.7*
Glycemia (mg/dL) 100.1 ± 2.4 96.8 ± 3.1 192.9 ± 3.7* 188.7 ± 1.3*
  1. Results are expressed as mean ± SEM. * p < 0.05 vs. respective control. n = 8–10 in each experimental group