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Table 5 Isolated papillary muscle data after positive inotropic stimulation

From: Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus

   SHR (n = 13) SHR-APO (n = 11) SHR-DM (n = 11) SHR-DM-APO (n = 10)
PP30 DT 13.7 ± 3.09 11.1 ± 1.69* 11.9 ± 3.01 10.3 ± 2.87
RT 1.04 ± 0.30 1.06 ± 0.31 1.24 ± 0.52 1.25 ± 0.62
+dT/dt 140 ± 33.4 115 ± 23.1* 105 ± 25.0* 95.2 ± 27.8
TPT 215 ± 17.1 209 ± 13.0 255 ± 27.0* 250 ± 22.6#
−dT/dt 42.6 ± 9.67 35.8 ± 4.58 32.4 ± 8.73* 25.1 ± 8.45
2.5 mM [Ca+2]0 DT 12.5 ± 2.78 10.3 ± 1.49 11.0 ± 2.95 9.79 ± 2.85
RT 0.87 ± 0.30 0.90 ± 0.31 0.90 ± 0.34 0.92 ± 0.52
+dT/dt 140 ± 31.9 117 ± 21.4 108 ± 28.0* 97.9 ± 28.7
TPT 192 ± 16.9 186 ± 17.8 224 ± 23.2* 216 ± 15.1#
−dT/dt 48.3 ± 10.6 40.0 ± 6.27 38.4 ± 11.6* 30.7 ± 10.2#
Iso 10−6 M DT 11.4 (8.33–13.5) 9.70 (8.77–10.1) 9.68 (8.60–10.1) 9.47 (6.08–10.8)
RT 0.85 ± 0.43 0.86 ± 0.34 0.84 ± 0.28 0.83 ± 0.52
+dT/dt 136 ± 34.0 118 ± 22.4 96.9 ± 26.6* 96.7 ± 31.7
TPT 163 ± 11.1 157 ± 9.49 184 ± 16.9* 190 ± 15.8#
−dT/dt 67.9 ± 16.6 58.3 ± 8.03 46.4 ± 13.4* 39.1 ± 13.7#
  1. Data are expressed as mean ± standard deviation or median and 25th and 75th percentile
  2. SHR spontaneously hypertensive rats; SHR-APO SHR treated with apocynin; SHR-DM diabetic SHR; SHR-DM-APO diabetic SHR treated with apocynin; PP30 30 s post-rest contraction; 2.5 mM [Ca +2 ] 0 extracellular Ca2+ concentration increased to 2.5 mM; Iso 10 6 M β-adrenergic agonist isoproterenol (10−6 M) added to the nutrient solution; DT peak of developed tension (g/mm2); RT resting tension (g/mm2); +dT/dt maximum rate of tension development (g/mm2/s); TPT time to peak tension (ms); −dT/dt maximum rate of tension decline (g/mm2/s)
  3. Two-factor ANOVA; * p < 0.05 vs SHR; # p < 0.05 vs SHR-APO; § p < 0.05 vs SHR-DM