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Table 3 Common genes from obese adipose tissue and atherosclerotic aortae involved in the oxidative phosphorylation pathway

From: Common dysregulated pathways in obese adipose tissue and atherosclerosis

Rank metric score

Gene symbol

Gene name

ATa

AOb

−2.2950

−0.4060

Maob

Monoamine oxidase B

−2.0570

−0.3260

Bckdha

Branched chain keto acid dehydrogenase E1, alpha polypeptide

−2.0250

−0.8910

Aldh6a1

Aldehyde dehydrogenase 6 family, member A1

−2.0020

−0.2060

Echs1

Enoyl CoA hydratase, short chain, 1, mitochondrial

−1.7080

−0.3710

Cox8a

Cytochrome c oxidase subunit 8a

−1.4980

−0.7180

Phyh

PhytanoylCoA hydroxylase

−1.4240

−0.1680

Cox4i1

Cytochrome c oxidase subunit IV isoform 1

−1.3880

−0.3800

Aco2

Aconitase 2, mitochondrial

−1.3400

−0.2640

Acat1

Acetyl-Coenzyme A acetyltransferase 1

−1.3350

−0.2220

Ndufb8

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8

−1.3200

−0.1620

Ndufv1

NADH dehydrogenase (ubiquinone) flavoprotein 1

−1.3060

−0.3470

Atp5d

ATP synthase, Htransporting, mitochondrial F1 complex, delta subunit

−1.2750

−0.2330

Ndufs7

NADH dehydrogenase (ubiquinone) FeS protein 7

−1.2670

−0.4190

Ndufa4

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4

−1.2370

−0.2430

Gpx4

Glutathione peroxidase 4

−1.2260

−0.4390

Pdha1

Pyruvate dehydrogenase E1 alpha 1

−1.2060

−0.4440

Sdhc

Succinate dehydrogenase complex, subunit C, integral membrane protein

−1.2030

−0.3650

Cs

Citrate synthase

−1.1660

−0.3270

Ndufa1

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1

−1.1510

−0.2410

Ndufa8

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8

−1.1450

−0.1990

Cox6b1

Cytochrome c oxidase subunit Vib polypeptide 1

−1.1290

−0.3140

Mrps15

Mitochondrial ribosomal protein S15

−1.1150

−0.2280

Idh3 g

Isocitrate dehydrogenase 3 (NAD+) gamma

−1.0870

−0.1990

Acadvl

Acyl-Coenzyme A dehydrogenase, very long chain

−1.0820

−0.1850

Ndufa9

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9

−1.0620

−0.3370

Cox6a1

Cytochrome c oxidase subunit VIa polypeptide 1

−1.0570

−0.2870

Ndufc1

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1

−1.0470

−0.1760

Mfn2

Mitofusin 2

−1.0230

−0.5940

Pdhb

Pyruvate dehydrogenase (lipoamide) beta

−1.0140

−0.3930

Idh3b

Isocitrate dehydrogenase 3 (NAD+) beta

−0.9750

−0.5050

Atp5g3

ATP synthase, H + transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

−0.9440

−0.1990

Uqcrfs1

Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

−0.9060

−0.2240

Mrpl34

Mitochondrial ribosomal protein L34

−0.8870

−0.2150

Uqcrh

Ubiquinol-cytochrome c reductase hinge protein

−0.8840

−0.3650

Grpel1

GrpElike 1, mitochondrial

−0.8440

−0.2340

Uqcrc2

Ubiquinol-cytochrome c reductase core protein 2

−0.8300

−0.1600

Ndufb6

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6

−0.8010

−0.5270

Ldhb

Lactate dehydrogenase B

−0.7460

−0.2100

Phb2

Prohibitin 2

−0.7320

−0.2170

Mrpl11

Mitochondrial ribosomal protein L11

−0.7270

−0.4530

Cox6c

Cytochrome c oxidase subunit VIc

−0.7160

−0.6190

Cox5b

Cytochrome c oxidase subunit Vb

−0.7090

−0.1590

Suclg1

Succinate-CoA ligase, GDP-forming, alpha subunit

−0.7080

−0.2300

Cox7b

Cytochrome c oxidase subunit VIIb

−0.7030

−0.1930

Atp5j

ATP synthase, Htransporting, mitochondrial F0 complex, subunit F

−0.6970

−0.3770

Cox5a

Cytochrome c oxidase subunit Va

−0.6920

−0.2190

Dlst

Dihydrolipoamide S-succinyltransferase

−0.6890

−0.2280

Atp5 h

ATP synthase, Htransporting, mitochondrial F0 complex, subunit D

−0.6880

−0.3350

Mdh1

Malate dehydrogenase 1, NAD (soluble)

−0.6860

−0.3760

Ndufb3

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3

−0.6670

−0.2560

Mrpl35

Mitochondrial ribosomal protein L35

−0.6340

−0.2650

Prdx3

Peroxiredoxin 3

−0.6270

−0.2690

Ndufa5

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5

−0.6050

−0.2480

Ndufb5

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5

−0.5830

−0.5650

Sdhd

Succinate dehydrogenase complex, subunit D, integral membrane protein

−0.5760

−0.1720

Ndufs8

NADH dehydrogenase (ubiquinone) FeS protein 8

  1. Dysregulated genes are sorted by descending rank metric score in AT
  2. aObese gonadal white adipose tissue
  3. bAtherosclerotic aortae