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Table 2 Common genes from obese adipose tissue and atherosclerotic aortae involved in the inflammatory response pathway

From: Common dysregulated pathways in obese adipose tissue and atherosclerosis

Rank metric score

Gene symbol

Gene name

ATa

AOb

4.554

2.000

Il7r

Interleukin 7 receptor

3.713

2.000

C3ar1

Complement component 3a receptor 1

3.652

0.928

Emr1

Adhesion G protein-coupled receptor E1

3.489

0.579

Tlr1

Toll-like receptor 1

3.298

1.000

Rgs1

Regulator of G-protein signalling 1

3.285

0.576

Semad4d

Semaphorin 4D

3.205

0.940

Cybb

Cytochrome b-245 heavy chain

3.175

0.445

Kcnj2

Inward rectifier potassium channel 2

3.111

0.779

C5ar1

C5a anaphylatoxin chemotactic receptor 1

3.037

1.000

Cd48

CD48 antigen

2.961

1.000

Pik3r5

Phosphoinositide-3-kinase, regulatory subunit 5, p101

2.626

0.992

Ptafr

Platelet-activating factor receptor

2.422

0.894

Ptpre

Protein tyrosine phosphatase, receptor type, E

2.364

0.716

P2rx4

Purinergic receptor P2X, ligand-gated ion channel, 4

2.346

2.000

Timp1

Tissue inhibitor of metalloproteinase 1

2.197

2.000

Il10ra

Interleukin 10 receptor, alpha

1.692

0.519

Plaur

Plasminogen activator, urokinase receptor

1.594

0.496

Clec5a

C-type lectin domain family 5, member a

1.535

0.361

Gna15

Guanine nucleotide binding protein, alpha 15

1.452

0.922

Ccl2

Chemokine (C–C motif) ligand 2

1.303

0.273

Ifnar1

Interferon (alpha and beta) receptor 1

1.129

0.957

Ccl7

Chemokine (C–C motif) ligand 7

1.090

1.000

Csf3r

Colony stimulating factor 3 receptor (granulocyte)

0.921

0.460

Il1r1

Interleukin 1 receptor, type I

0.905

0.697

Ccl5

Chemokine (C–C motif) ligand 5

0.882

0.782

Icam1

Intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

0.806

0.277

Slc11a2

Solute carrier family 11, member 2

  1. Dysregulated genes are sorted by descending rank metric score in AT
  2. aObese gonadal white adipose tissue
  3. bAtherosclerotic aortae