Cardiovascular Diabetology

Table 1 Dysregulated pathways from obese adipose tissue and atherosclerotic aortae after Hallmark-GSEA analysis

From: Common dysregulated pathways in obese adipose tissue and atherosclerosis

DP^a		NES^d		NOM p-Val^e		FDR^f		IRP^g	MRP^h	Name
AT^b	AO^c	AT	AO	AT	AO	AT	AO	IRP^g	MRP^h	Name
x	x	2.43	1.35	<0.001	0.047	0.000	0.098			E2F targets
x	x	2.39	1.74	<0.001	<0.001	0.000	0.004			G2 M checkpoint
x	x	2.15	2.27	<0.001	<0.001	0.000	0.000	x		Allograft rejection
x	x	2.12	2.33	<0.001	<0.001	0.000	0.000	x		Inflammatory response
x	x	2.08	1.99	<0.001	<0.001	0.000	0.001	x		IL6 JAK STAT3 signaling
x	x	1.99	1.90	<0.001	<0.001	0.000	0.001			Epithelial mesenchymal transition
x	x	1.97	1.97	<0.001	<0.001	0.000		x		TNFA signaling via NFKB
x	x	1.88	1.75	<0.001	<0.001	0.000				Mitotic spindle
x	x	1.86	2.10	<0.001	<0.001	0.000	0.000			Complement
x	x	1.86	2.10	<0.001	<0.001	0.000		x		Kras signaling up
x	x	1.81	1.41	0.002	0.045	0.001				Protein secretion
x	x	1.72	1.89	<0.001	<0.001	0.004	0.001			Apoptosis
x	x	1.63	–1.34	0.001	0.026	0.008	0.091		x	MTORC1 signaling
x	x	1.60	2.35	0.001	<0.001	0.011	0.000	x		Interferon gamma response
x	x	1.58	1.61	0.021	0.021	0.013	0.011		x	Angiogenesis
x	x	1.50	1.48	0.006	0.012	0.027	0.035			Coagulation
x		1.48		0.012		0.030				Unfolded protein response
x		1.43		0.015		0.047				MYC targets V1
x		1.41		0.024		0.051			x	Androgen response
x		1.36		0.027		0.073		x		IL2 STAT5 signaling
x	x	1.34	1.68	0.024	<0.001	0.084				P53 pathway
x	x	−1.45	−1.72	0.016	<0.001	0.036	0.004		x	Peroxisome
x		−1.56		<0.001		0.000				Myogenesis
x	x	−1.65	−2.14	<0.001	<0.001	0.000	0.000		x	Bile acid metabolism
x	x	−1.86	–1.46	<0.001	0.003	0.000	0.038			Xenobiotic metabolism
x	x	–2.17	–2.40	<0.001	<0.001	0.000	0.000		x	Fatty acid metabolism
x	x	–2.44	−2.15	<0.001	<0.001	0.000	0.000		x	Oxidative phosphorylation
x	x	−3.06	−2.38	<0.001	<0.001	0.000	0.000		x	Adipogenesis
	x		2.08		<0.001		0.000	x		Interferon alpha response
	x		1.72		<0.001		0.005			Heme metabolism
	x		1.63		0.001		0.010			Apical junction
	x		1.50		0.007		0.031		x	Hypoxia
	x		–1.77	<0.001			0.002			Spermatogenesis

Commonly dysregulated pathways in AT and AO are shown in italics
Dysregulated pathways are sorted by descending NES in AT
^aDysregulated pathways
^bObese white adipose tissue
^cAtherosclerosic aortae
^dNormalized enrichment score
^eNominal p value
^fFalse discovery rate
^gInflammation related pathways
^hMetabolism related pathways

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