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Table 1 Dysregulated pathways from obese adipose tissue and atherosclerotic aortae after Hallmark-GSEA analysis

From: Common dysregulated pathways in obese adipose tissue and atherosclerosis

DPa NESd NOM p-Vale FDRf IRPg MRPh Name
ATb AOc AT AO AT AO AT AO
x x 2.43 1.35 <0.001 0.047 0.000 0.098    E2F targets
x x 2.39 1.74 <0.001 <0.001 0.000 0.004    G2 M checkpoint
x x 2.15 2.27 <0.001 <0.001 0.000 0.000 x   Allograft rejection
x x 2.12 2.33 <0.001 <0.001 0.000 0.000 x   Inflammatory response
x x 2.08 1.99 <0.001 <0.001 0.000 0.001 x   IL6 JAK STAT3 signaling
x x 1.99 1.90 <0.001 <0.001 0.000 0.001    Epithelial mesenchymal transition
x x 1.97 1.97 <0.001 <0.001 0.000   x   TNFA signaling via NFKB
x x 1.88 1.75 <0.001 <0.001 0.000     Mitotic spindle
x x 1.86 2.10 <0.001 <0.001 0.000 0.000    Complement
x x 1.86 2.10 <0.001 <0.001 0.000   x   Kras signaling up
x x 1.81 1.41 0.002 0.045 0.001     Protein secretion
x x 1.72 1.89 <0.001 <0.001 0.004 0.001    Apoptosis
x x 1.63 –1.34 0.001 0.026 0.008 0.091   x MTORC1 signaling
x x 1.60 2.35 0.001 <0.001 0.011 0.000 x   Interferon gamma response
x x 1.58 1.61 0.021 0.021 0.013 0.011   x Angiogenesis
x x 1.50 1.48 0.006 0.012 0.027 0.035    Coagulation
x   1.48   0.012   0.030     Unfolded protein response
x   1.43   0.015   0.047     MYC targets V1
x   1.41   0.024   0.051    x Androgen response
x   1.36   0.027   0.073   x   IL2 STAT5 signaling
x x 1.34 1.68 0.024 <0.001 0.084     P53 pathway
x x −1.45 −1.72 0.016 <0.001 0.036 0.004   x Peroxisome
x   −1.56   <0.001   0.000     Myogenesis
x x −1.65 −2.14 <0.001 <0.001 0.000 0.000   x Bile acid metabolism
x x −1.86 –1.46 <0.001 0.003 0.000 0.038    Xenobiotic metabolism
x x –2.17 –2.40 <0.001 <0.001 0.000 0.000   x Fatty acid metabolism
x x –2.44 −2.15 <0.001 <0.001 0.000 0.000   x Oxidative phosphorylation
x x −3.06 −2.38 <0.001 <0.001 0.000 0.000   x Adipogenesis
  x   2.08   <0.001   0.000 x   Interferon alpha response
  x   1.72   <0.001   0.005    Heme metabolism
  x   1.63   0.001   0.010    Apical junction
  x   1.50   0.007   0.031   x Hypoxia
  x   –1.77 <0.001    0.002    Spermatogenesis
  1. Commonly dysregulated pathways in AT and AO are shown in italics
  2. Dysregulated pathways are sorted by descending NES in AT
  3. aDysregulated pathways
  4. bObese white adipose tissue
  5. cAtherosclerosic aortae
  6. dNormalized enrichment score
  7. eNominal p value
  8. fFalse discovery rate
  9. gInflammation related pathways
  10. hMetabolism related pathways
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Cardiovascular Diabetology

ISSN: 1475-2840