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Table 6 Metabolomic HDL traits with an association with rs10911021 in diabetic participants

From: Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

Trait (mol/l) Number of non-T2D participants Beta-effect in non-T2D participants (se) p value FDR adjusted p value Heterogeneity [I2 (%)] Number of T2D participants Beta-effect in T2D participants (se) p value FDR adjusted p value Heterogeneity [I2 (%)] p value for conditional analysis with rs1689800 FDR adjusted p value for conditional analysis with rs1689800
Concentration of large HDL particles 5221 0.01 (0.02) 0.59 1 0 1310 −0.15 (0.04) 0.0005 0.03 0 0.001 0.07
Total lipids in large HDL 5229 0.01 (0.02) 0.62 1 0 1310 −0.15 (0.04) 0.0005 0.03 0 0.001 0.07
Phospholipids in large HDL 5223 0.01 (0.02) 0.59 1 0 1310 −0.14 (0.04) 0.0009 0.03 0 0.002 0.09
Total cholesterol in large HDL 5223 0.008 (0.02) 0.71 1 0 1310 −0.15 (0.04) 0.0004 0.04 0 0.001 0.07
Cholesterol esters in large HDL 5221 0.009 (0.02) 0.67 1 0 1310 −0.15 (0.04) 0.0004 0.03 0 0.001 0.07
Free cholesterol in large HDL 5221 0.005 (0.02) 0.83 1 0 1310 −0.16 (0.04) 0.0003 0.03 0 0.0009 0.07
  1. Beta-effects corresponding to the minor allele are shown, along with the standard errors. FDR analysis was performed using the Benjamini-Hochberg-Yekutieli method. When the use of lipid lowering therapy was not included in the linear regression model, the results remained directionally similar, but the statistical significance of the effects was reduced
  2. FDR false discovery rate