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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): from bedside to bench

Fig. 2

Telmisartan decreased diabetes-induced cardiac fibrosis in STZ rats via PPARδ. a Hematoxylin and eosin and Masson trichrome staining of control (Sham) rat hearts, STZ-treated rat hearts, and STZ-treated rat hearts treated with telmisartan, telmisartan plus GSK0660 (a PPARδ antagonist), or metformin. b The expression of PPARδ, STAT3, CTGF, and MMP9 proteins in the variously treated rat hearts. c The relative expression of PPARδ, STAT3, CTGF, and MMP9 in variously treated rat hearts. STZ streptozotocin, Tel telmisartan, PPARδ peroxisome proliferator-activated receptor δ, STAT3 signal transducer and activator of transcription 3, CTGF connective tissue growth factor, MMP9 matrix metallopeptidase 9

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