Parameter
|
SAL
|
CHG
|
AFG
|
---|
Ach potency (−log EC50)
|
7.9 ± 0.05
|
7.8 ± 0.06
|
7.2 ± 0.08*
|
Ach efficacy (max, relaxation, %)
|
98 ± 1.2
|
96 ± 2.4
|
75 ± 1.8*
|
- SAL (SAL group rats underwent 48 h infusions with saline); CHG (CHG group rats underwent 48 h infusions with 50 % glucose continually to keep the glucose concentration at 20 ± 0.5 mmol/l); AFG (AFG group rats underwent 48 h infusions with 50 % glucose intermittently so that blood glucose alternated between 5.5 ± 0.5 and 20 ± 0.5 mmol/l). Data are mean ± SD. n = 10/group. * P < 0.05 vs SAL