Skip to main content

Table 4 Gene ontology analysis

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Category

Term

Count

%

P value

Gene symbol

GOTERM_BP_1

GO:0065007 ~ biological regulation

48

41.74

0.01

FGF18, PDIA2, GPBP1, C3, CRABP2, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CCNG1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1,DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, LOC501307, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1

GOTERM_BP_2

GO:0006950 ~ response to stress

16

13.91

0.04

NCF1, PDIA2, C3, SGMS1, CD1D1, STAT3, ALDH1A1, ERCC8, SDC1, PLOD2, CHRNA7, TRAF6, EIF2AK2, DDAH1, DPP4, BARD1

GOTERM_BP_2

GO:0050789 ~ regulation of biological process

45

39.13

0.02

FGF18, PDIA2, GPBP1, C3, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1, DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1

GOTERM_BP_2

GO:0048518 ~ positive regulation of biological process

24

20.87

0.00

FGF18, C3, GPBP1, ZEB2, TRIM16, ARNTL, LPAR1, CD1D1, STAT3, FMN1, ALDH1A1, ATP2B2, CD47, NPAS2, JUND, KLRE1, TEF, CHRNA7, EIF2AK2, TRAF6, DDAH1, ICOSLG, CYR61, BARD1

GOTERM_BP_2

GO:0048646 ~ anatomical structure formation involved in morphogenesis

9

7.83

0.00

ALDH1A1, ATP2B2, FGF18, RET, RIPPLY2, ZEB2, TRAF6, DDAH1, CYR61

GOTERM_BP_2

GO:0009653 ~ anatomical structure morphogenesis

14

12.17

0.03

FMN1, ALDH1A1, ATP2B2, FGF18, SDC1, RET, EFNA2, CRABP2, RIPPLY2, ZEB2, TRAF6, DDAH1, STAT3, CYR61

GOTERM_BP_1

GO:0008152 ~ metabolic process

48

41.74

0.03

CYP2J4, OCLN, C3, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, PLOD2, ZFP90, CPOX, P4HA3, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, DPP4, RET, NCF1, PRKAB2, LOC501307, ARNTL, CRYZ, TMEM189, LPCAT2, PRKCE, WEE1, STAT3, RPS7, OXSM, FMN1, TAF13, SLC16A7, AKR1B10, PLA2G7, CMA1, EIF2AK2, CAR6, PRPS2, BARD1

GOTERM_BP_2

GO:0044237 ~ cellular metabolic process

39

33.91

0.09

CYP2J4, OCLN, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, ZFP90, CPOX, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, RET, NCF1, PRKAB2, LOC501307, ARNTL, TMEM189, PRKCE, LPCAT2, WEE1, STAT3, RPS7, OXSM, TAF13, SLC16A7, EIF2AK2, CAR6, PRPS2, BARD1

GOTERM_BP_3

GO:0034641 ~ cellular nitrogen compound metabolic process

19

16.52

0.09

OCLN, LOC501307, ARNTL, LPCAT2, STAT3, RPS7, ERCC8, ATP2B2, MCM8, TAF13, ZFP90, CPOX, JUND, TEF, PER2, CHRNA7, DDAH1, PRPS2, BARD1

GOTERM_BP_4

GO:0006575 ~ cellular amino acid derivative metabolic process

4

3.48

0.10

ATP2B2, OCLN, CHRNA7, LPCAT2

GOTERM_BP_3

GO:0010033 ~ response to organic substance

11

9.57

0.09

ALDH1A1, CYP2J4, SDC1, JUND, TRIM16, CHRNA7, GNB3, EIF2AK2, DDAH1, STAT3, CYR61

GOTERM_BP_4

GO:0014070 ~ response to organic cyclic substance

5

4.35

0.05

ALDH1A1, CYP2J4, JUND, CHRNA7, STAT3

GOTERM_BP_3

GO:0006629 ~ lipid metabolic process

9

7.83

0.08

ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, PLA2G7, SGMS1, LPCAT2, OXSM

GOTERM_BP_4

GO:0006720 ~ isoprenoid metabolic process

3

2.61

0.06

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_5

GO:0006720 ~ isoprenoid metabolic process

3

2.61

0.05

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_5

GO:0001523 ~ retinoid metabolic process

3

2.61

0.02

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_4

GO:0042573 ~ retinoic acid metabolic process

2

1.74

0.10

ALDH1A1, CRABP2

GOTERM_BP_3

GO:0044255 ~ cellular lipid metabolic process

8

6.96

0.04

ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM

GOTERM_BP_4

GO:0044255 ~ cellular lipid metabolic process

8

6.96

0.04

ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM

GOTERM_BP_3

GO:0006082 ~ organic acid metabolic process

8

6.96

0.06

ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM

GOTERM_BP_4

GO:0043436 ~ oxoacid metabolic process

8

6.96

0.06

ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM

GOTERM_BP_5

GO:0019752 ~ carboxylic acid metabolic process

8

6.96

0.05

ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM

GOTERM_BP_3

GO:0042180 ~ cellular ketone metabolic process

8

6.96

0.07

ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM

GOTERM_BP_3

GO:0006721 ~ terpenoid metabolic process

3

2.61

0.02

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_4

GO:0016101 ~ diterpenoid metabolic process

3

2.61

0.02

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_5

GO:0006721 ~ terpenoid metabolic process

3

2.61

0.02

ALDH1A1, CYP2J4, CRABP2

GOTERM_BP_1

GO:0002376 ~ immune system process

10

8.70

0.05

CD47, NCF1, C3, RT1-T18, KLRE1, CHRNA7, TRAF6, CD1D1, DDAH1, DPP4

GOTERM_BP_2

GO:0045321 ~ leukocyte activation

5

4.35

0.06

KLRE1, CHRNA7, TRAF6, CD1D1, DPP4

GOTERM_BP_3

GO:0045321 ~ leukocyte activation

5

4.35

0.05

KLRE1, CHRNA7, TRAF6, CD1D1, DPP4

GOTERM_BP_4

GO:0046649 ~ lymphocyte activation

4

3.48

0.10

KLRE1, CHRNA7, CD1D1, DPP4

GOTERM_BP_2

GO:0006955 ~ immune response

7

6.09

0.06

CD47, NCF1, C3, RT1-T18, TRAF6, CD1D1, DDAH1

GOTERM_BP_2

GO:0002682 ~ regulation of immune system process

7

6.09

0.04

CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4

GOTERM_BP_3

GO:0050776 ~ regulation of immune response

6

5.22

0.02

C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4

GOTERM_BP_4

GO:0050776 ~ regulation of immune response

6

5.22

0.01

C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4

GOTERM_BP_5

GO:0002253 ~ activation of immune response

4

3.48

0.02

C3, KLRE1, TRAF6, DDAH1

GOTERM_BP_4

GO:0002697 ~ regulation of immune effector process

5

4.35

0.01

C3, KLRE1, TRAF6, CD1D1, DPP4

GOTERM_BP_5

GO:0002697 ~ regulation of immune effector process

5

4.35

0.00

C3, KLRE1, TRAF6, CD1D1, DPP4

GOTERM_BP_5

GO:0002706 ~ regulation of lymphocyte mediated immunity

5

4.35

0.00

C3, KLRE1, TRAF6, CD1D1, DPP4

GOTERM_BP_5

GO:0002703 ~ regulation of leukocyte mediated immunity

5

4.35

0.00

C3, KLRE1, TRAF6, CD1D1, DPP4

GOTERM_BP_4

GO:0002819 ~ regulation of adaptive immune response

4

3.48

0.01

C3, TRAF6, CD1D1, DPP4

GOTERM_BP_3

GO:0002682 ~ regulation of immune system process

7

6.09

0.04

CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4

GOTERM_BP_4

GO:0002684 ~ positive regulation of immune system process

6

5.22

0.02

CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1

GOTERM_BP_2

GO:0002252 ~ immune effector process

4

3.48

0.05

CD47, NCF1, C3, DDAH1

GOTERM_BP_3

GO:0002252 ~ immune effector process

4

3.48

0.05

CD47, NCF1, C3, DDAH1

GOTERM_BP_4

GO:0006968 ~ cellular defense response

2

1.74

0.05

NCF1, DDAH1

GOTERM_BP_1

GO:0022610 ~ biological adhesion

7

6.09

0.09

CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61

GOTERM_BP_2

GO:0007155 ~ cell adhesion

7

6.09

0.09

CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61

GOTERM_BP_1

GO:0048511 ~ rhythmic process

7

6.09

0.00

ALDH1A1, NPAS2, JUND, PER2, TEF, CHRNA7, ARNTL

GOTERM_BP_2

GO:0007623 ~ circadian rhythm

4

3.48

0.01

NPAS2, JUND, PER2, ARNTL

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840