Table 4 Gene ontology analysis
From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
| Category | Term | Count | % | P value | Gene symbol |
|---|---|---|---|---|---|
| GOTERM_BP_1 | GO:0065007 ~ biological regulation | 48 | 41.74 | 0.01 | FGF18, PDIA2, GPBP1, C3, CRABP2, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CCNG1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1,DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, LOC501307, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1 |
| GOTERM_BP_2 | GO:0006950 ~ response to stress | 16 | 13.91 | 0.04 | NCF1, PDIA2, C3, SGMS1, CD1D1, STAT3, ALDH1A1, ERCC8, SDC1, PLOD2, CHRNA7, TRAF6, EIF2AK2, DDAH1, DPP4, BARD1 |
| GOTERM_BP_2 | GO:0050789 ~ regulation of biological process | 45 | 39.13 | 0.02 | FGF18, PDIA2, GPBP1, C3, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1, DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1 |
| GOTERM_BP_2 | GO:0048518 ~ positive regulation of biological process | 24 | 20.87 | 0.00 | FGF18, C3, GPBP1, ZEB2, TRIM16, ARNTL, LPAR1, CD1D1, STAT3, FMN1, ALDH1A1, ATP2B2, CD47, NPAS2, JUND, KLRE1, TEF, CHRNA7, EIF2AK2, TRAF6, DDAH1, ICOSLG, CYR61, BARD1 |
| GOTERM_BP_2 | GO:0048646 ~ anatomical structure formation involved in morphogenesis | 9 | 7.83 | 0.00 | ALDH1A1, ATP2B2, FGF18, RET, RIPPLY2, ZEB2, TRAF6, DDAH1, CYR61 |
| GOTERM_BP_2 | GO:0009653 ~ anatomical structure morphogenesis | 14 | 12.17 | 0.03 | FMN1, ALDH1A1, ATP2B2, FGF18, SDC1, RET, EFNA2, CRABP2, RIPPLY2, ZEB2, TRAF6, DDAH1, STAT3, CYR61 |
| GOTERM_BP_1 | GO:0008152 ~ metabolic process | 48 | 41.74 | 0.03 | CYP2J4, OCLN, C3, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, PLOD2, ZFP90, CPOX, P4HA3, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, DPP4, RET, NCF1, PRKAB2, LOC501307, ARNTL, CRYZ, TMEM189, LPCAT2, PRKCE, WEE1, STAT3, RPS7, OXSM, FMN1, TAF13, SLC16A7, AKR1B10, PLA2G7, CMA1, EIF2AK2, CAR6, PRPS2, BARD1 |
| GOTERM_BP_2 | GO:0044237 ~ cellular metabolic process | 39 | 33.91 | 0.09 | CYP2J4, OCLN, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, ZFP90, CPOX, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, RET, NCF1, PRKAB2, LOC501307, ARNTL, TMEM189, PRKCE, LPCAT2, WEE1, STAT3, RPS7, OXSM, TAF13, SLC16A7, EIF2AK2, CAR6, PRPS2, BARD1 |
| GOTERM_BP_3 | GO:0034641 ~ cellular nitrogen compound metabolic process | 19 | 16.52 | 0.09 | OCLN, LOC501307, ARNTL, LPCAT2, STAT3, RPS7, ERCC8, ATP2B2, MCM8, TAF13, ZFP90, CPOX, JUND, TEF, PER2, CHRNA7, DDAH1, PRPS2, BARD1 |
| GOTERM_BP_4 | GO:0006575 ~ cellular amino acid derivative metabolic process | 4 | 3.48 | 0.10 | ATP2B2, OCLN, CHRNA7, LPCAT2 |
| GOTERM_BP_3 | GO:0010033 ~ response to organic substance | 11 | 9.57 | 0.09 | ALDH1A1, CYP2J4, SDC1, JUND, TRIM16, CHRNA7, GNB3, EIF2AK2, DDAH1, STAT3, CYR61 |
| GOTERM_BP_4 | GO:0014070 ~ response to organic cyclic substance | 5 | 4.35 | 0.05 | ALDH1A1, CYP2J4, JUND, CHRNA7, STAT3 |
| GOTERM_BP_3 | GO:0006629 ~ lipid metabolic process | 9 | 7.83 | 0.08 | ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, PLA2G7, SGMS1, LPCAT2, OXSM |
| GOTERM_BP_4 | GO:0006720 ~ isoprenoid metabolic process | 3 | 2.61 | 0.06 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_5 | GO:0006720 ~ isoprenoid metabolic process | 3 | 2.61 | 0.05 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_5 | GO:0001523 ~ retinoid metabolic process | 3 | 2.61 | 0.02 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_4 | GO:0042573 ~ retinoic acid metabolic process | 2 | 1.74 | 0.10 | ALDH1A1, CRABP2 |
| GOTERM_BP_3 | GO:0044255 ~ cellular lipid metabolic process | 8 | 6.96 | 0.04 | ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM |
| GOTERM_BP_4 | GO:0044255 ~ cellular lipid metabolic process | 8 | 6.96 | 0.04 | ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM |
| GOTERM_BP_3 | GO:0006082 ~ organic acid metabolic process | 8 | 6.96 | 0.06 | ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM |
| GOTERM_BP_4 | GO:0043436 ~ oxoacid metabolic process | 8 | 6.96 | 0.06 | ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM |
| GOTERM_BP_5 | GO:0019752 ~ carboxylic acid metabolic process | 8 | 6.96 | 0.05 | ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM |
| GOTERM_BP_3 | GO:0042180 ~ cellular ketone metabolic process | 8 | 6.96 | 0.07 | ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM |
| GOTERM_BP_3 | GO:0006721 ~ terpenoid metabolic process | 3 | 2.61 | 0.02 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_4 | GO:0016101 ~ diterpenoid metabolic process | 3 | 2.61 | 0.02 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_5 | GO:0006721 ~ terpenoid metabolic process | 3 | 2.61 | 0.02 | ALDH1A1, CYP2J4, CRABP2 |
| GOTERM_BP_1 | GO:0002376 ~ immune system process | 10 | 8.70 | 0.05 | CD47, NCF1, C3, RT1-T18, KLRE1, CHRNA7, TRAF6, CD1D1, DDAH1, DPP4 |
| GOTERM_BP_2 | GO:0045321 ~ leukocyte activation | 5 | 4.35 | 0.06 | KLRE1, CHRNA7, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_3 | GO:0045321 ~ leukocyte activation | 5 | 4.35 | 0.05 | KLRE1, CHRNA7, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_4 | GO:0046649 ~ lymphocyte activation | 4 | 3.48 | 0.10 | KLRE1, CHRNA7, CD1D1, DPP4 |
| GOTERM_BP_2 | GO:0006955 ~ immune response | 7 | 6.09 | 0.06 | CD47, NCF1, C3, RT1-T18, TRAF6, CD1D1, DDAH1 |
| GOTERM_BP_2 | GO:0002682 ~ regulation of immune system process | 7 | 6.09 | 0.04 | CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4 |
| GOTERM_BP_3 | GO:0050776 ~ regulation of immune response | 6 | 5.22 | 0.02 | C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4 |
| GOTERM_BP_4 | GO:0050776 ~ regulation of immune response | 6 | 5.22 | 0.01 | C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4 |
| GOTERM_BP_5 | GO:0002253 ~ activation of immune response | 4 | 3.48 | 0.02 | C3, KLRE1, TRAF6, DDAH1 |
| GOTERM_BP_4 | GO:0002697 ~ regulation of immune effector process | 5 | 4.35 | 0.01 | C3, KLRE1, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_5 | GO:0002697 ~ regulation of immune effector process | 5 | 4.35 | 0.00 | C3, KLRE1, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_5 | GO:0002706 ~ regulation of lymphocyte mediated immunity | 5 | 4.35 | 0.00 | C3, KLRE1, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_5 | GO:0002703 ~ regulation of leukocyte mediated immunity | 5 | 4.35 | 0.00 | C3, KLRE1, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_4 | GO:0002819 ~ regulation of adaptive immune response | 4 | 3.48 | 0.01 | C3, TRAF6, CD1D1, DPP4 |
| GOTERM_BP_3 | GO:0002682 ~ regulation of immune system process | 7 | 6.09 | 0.04 | CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4 |
| GOTERM_BP_4 | GO:0002684 ~ positive regulation of immune system process | 6 | 5.22 | 0.02 | CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1 |
| GOTERM_BP_2 | GO:0002252 ~ immune effector process | 4 | 3.48 | 0.05 | CD47, NCF1, C3, DDAH1 |
| GOTERM_BP_3 | GO:0002252 ~ immune effector process | 4 | 3.48 | 0.05 | CD47, NCF1, C3, DDAH1 |
| GOTERM_BP_4 | GO:0006968 ~ cellular defense response | 2 | 1.74 | 0.05 | NCF1, DDAH1 |
| GOTERM_BP_1 | GO:0022610 ~ biological adhesion | 7 | 6.09 | 0.09 | CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61 |
| GOTERM_BP_2 | GO:0007155 ~ cell adhesion | 7 | 6.09 | 0.09 | CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61 |
| GOTERM_BP_1 | GO:0048511 ~ rhythmic process | 7 | 6.09 | 0.00 | ALDH1A1, NPAS2, JUND, PER2, TEF, CHRNA7, ARNTL |
| GOTERM_BP_2 | GO:0007623 ~ circadian rhythm | 4 | 3.48 | 0.01 | NPAS2, JUND, PER2, ARNTL |