Skip to main content

Table 4 Gene ontology analysis

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Category Term Count % P value Gene symbol
GOTERM_BP_1 GO:0065007 ~ biological regulation 48 41.74 0.01 FGF18, PDIA2, GPBP1, C3, CRABP2, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CCNG1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1,DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, LOC501307, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1
GOTERM_BP_2 GO:0006950 ~ response to stress 16 13.91 0.04 NCF1, PDIA2, C3, SGMS1, CD1D1, STAT3, ALDH1A1, ERCC8, SDC1, PLOD2, CHRNA7, TRAF6, EIF2AK2, DDAH1, DPP4, BARD1
GOTERM_BP_2 GO:0050789 ~ regulation of biological process 45 39.13 0.02 FGF18, PDIA2, GPBP1, C3, TRIM16, ZEB2, LPAR1, ESM1, SGMS1, CD1D1, ALDH1A1, ATP2B2, CD47, NPAS2, DGKB, ZFP90, CXCR6, JUND, PER2, TEF, CHRNA7, CNTNAP1, TRAF6, QSOX1, DDAH1, DPP4, DPT, CYR61, RET, NCF1, NUCKS1, ARHGEF5, PRKAB2, ARNTL, PTGFR, PRKCE, TMEM189, STAT3, FMN1, TRPS1, KLRE1, GNB3, EIF2AK2, ICOSLG, BARD1
GOTERM_BP_2 GO:0048518 ~ positive regulation of biological process 24 20.87 0.00 FGF18, C3, GPBP1, ZEB2, TRIM16, ARNTL, LPAR1, CD1D1, STAT3, FMN1, ALDH1A1, ATP2B2, CD47, NPAS2, JUND, KLRE1, TEF, CHRNA7, EIF2AK2, TRAF6, DDAH1, ICOSLG, CYR61, BARD1
GOTERM_BP_2 GO:0048646 ~ anatomical structure formation involved in morphogenesis 9 7.83 0.00 ALDH1A1, ATP2B2, FGF18, RET, RIPPLY2, ZEB2, TRAF6, DDAH1, CYR61
GOTERM_BP_2 GO:0009653 ~ anatomical structure morphogenesis 14 12.17 0.03 FMN1, ALDH1A1, ATP2B2, FGF18, SDC1, RET, EFNA2, CRABP2, RIPPLY2, ZEB2, TRAF6, DDAH1, STAT3, CYR61
GOTERM_BP_1 GO:0008152 ~ metabolic process 48 41.74 0.03 CYP2J4, OCLN, C3, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, PLOD2, ZFP90, CPOX, P4HA3, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, DPP4, RET, NCF1, PRKAB2, LOC501307, ARNTL, CRYZ, TMEM189, LPCAT2, PRKCE, WEE1, STAT3, RPS7, OXSM, FMN1, TAF13, SLC16A7, AKR1B10, PLA2G7, CMA1, EIF2AK2, CAR6, PRPS2, BARD1
GOTERM_BP_2 GO:0044237 ~ cellular metabolic process 39 33.91 0.09 CYP2J4, OCLN, CRABP2, TRIM50, TRIM16, LPAR1, SGMS1, ALDH1A1, ATP2B2, ERCC8, MCM8, ST6GALNAC3, ZFP90, CPOX, JUND, PER2, TEF, CHRNA7, TRAF6, QSOX1, DDAH1, RET, NCF1, PRKAB2, LOC501307, ARNTL, TMEM189, PRKCE, LPCAT2, WEE1, STAT3, RPS7, OXSM, TAF13, SLC16A7, EIF2AK2, CAR6, PRPS2, BARD1
GOTERM_BP_3 GO:0034641 ~ cellular nitrogen compound metabolic process 19 16.52 0.09 OCLN, LOC501307, ARNTL, LPCAT2, STAT3, RPS7, ERCC8, ATP2B2, MCM8, TAF13, ZFP90, CPOX, JUND, TEF, PER2, CHRNA7, DDAH1, PRPS2, BARD1
GOTERM_BP_4 GO:0006575 ~ cellular amino acid derivative metabolic process 4 3.48 0.10 ATP2B2, OCLN, CHRNA7, LPCAT2
GOTERM_BP_3 GO:0010033 ~ response to organic substance 11 9.57 0.09 ALDH1A1, CYP2J4, SDC1, JUND, TRIM16, CHRNA7, GNB3, EIF2AK2, DDAH1, STAT3, CYR61
GOTERM_BP_4 GO:0014070 ~ response to organic cyclic substance 5 4.35 0.05 ALDH1A1, CYP2J4, JUND, CHRNA7, STAT3
GOTERM_BP_3 GO:0006629 ~ lipid metabolic process 9 7.83 0.08 ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, PLA2G7, SGMS1, LPCAT2, OXSM
GOTERM_BP_4 GO:0006720 ~ isoprenoid metabolic process 3 2.61 0.06 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_5 GO:0006720 ~ isoprenoid metabolic process 3 2.61 0.05 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_5 GO:0001523 ~ retinoid metabolic process 3 2.61 0.02 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_4 GO:0042573 ~ retinoic acid metabolic process 2 1.74 0.10 ALDH1A1, CRABP2
GOTERM_BP_3 GO:0044255 ~ cellular lipid metabolic process 8 6.96 0.04 ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM
GOTERM_BP_4 GO:0044255 ~ cellular lipid metabolic process 8 6.96 0.04 ALDH1A1, CYP2J4, NCF1, CRABP2, PRKAB2, SGMS1, LPCAT2, OXSM
GOTERM_BP_3 GO:0006082 ~ organic acid metabolic process 8 6.96 0.06 ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM
GOTERM_BP_4 GO:0043436 ~ oxoacid metabolic process 8 6.96 0.06 ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM
GOTERM_BP_5 GO:0019752 ~ carboxylic acid metabolic process 8 6.96 0.05 ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM
GOTERM_BP_3 GO:0042180 ~ cellular ketone metabolic process 8 6.96 0.07 ALDH1A1, CYP2J4, SLC16A7, NCF1, CRABP2, PRKAB2, DDAH1, OXSM
GOTERM_BP_3 GO:0006721 ~ terpenoid metabolic process 3 2.61 0.02 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_4 GO:0016101 ~ diterpenoid metabolic process 3 2.61 0.02 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_5 GO:0006721 ~ terpenoid metabolic process 3 2.61 0.02 ALDH1A1, CYP2J4, CRABP2
GOTERM_BP_1 GO:0002376 ~ immune system process 10 8.70 0.05 CD47, NCF1, C3, RT1-T18, KLRE1, CHRNA7, TRAF6, CD1D1, DDAH1, DPP4
GOTERM_BP_2 GO:0045321 ~ leukocyte activation 5 4.35 0.06 KLRE1, CHRNA7, TRAF6, CD1D1, DPP4
GOTERM_BP_3 GO:0045321 ~ leukocyte activation 5 4.35 0.05 KLRE1, CHRNA7, TRAF6, CD1D1, DPP4
GOTERM_BP_4 GO:0046649 ~ lymphocyte activation 4 3.48 0.10 KLRE1, CHRNA7, CD1D1, DPP4
GOTERM_BP_2 GO:0006955 ~ immune response 7 6.09 0.06 CD47, NCF1, C3, RT1-T18, TRAF6, CD1D1, DDAH1
GOTERM_BP_2 GO:0002682 ~ regulation of immune system process 7 6.09 0.04 CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4
GOTERM_BP_3 GO:0050776 ~ regulation of immune response 6 5.22 0.02 C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4
GOTERM_BP_4 GO:0050776 ~ regulation of immune response 6 5.22 0.01 C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4
GOTERM_BP_5 GO:0002253 ~ activation of immune response 4 3.48 0.02 C3, KLRE1, TRAF6, DDAH1
GOTERM_BP_4 GO:0002697 ~ regulation of immune effector process 5 4.35 0.01 C3, KLRE1, TRAF6, CD1D1, DPP4
GOTERM_BP_5 GO:0002697 ~ regulation of immune effector process 5 4.35 0.00 C3, KLRE1, TRAF6, CD1D1, DPP4
GOTERM_BP_5 GO:0002706 ~ regulation of lymphocyte mediated immunity 5 4.35 0.00 C3, KLRE1, TRAF6, CD1D1, DPP4
GOTERM_BP_5 GO:0002703 ~ regulation of leukocyte mediated immunity 5 4.35 0.00 C3, KLRE1, TRAF6, CD1D1, DPP4
GOTERM_BP_4 GO:0002819 ~ regulation of adaptive immune response 4 3.48 0.01 C3, TRAF6, CD1D1, DPP4
GOTERM_BP_3 GO:0002682 ~ regulation of immune system process 7 6.09 0.04 CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1, DPP4
GOTERM_BP_4 GO:0002684 ~ positive regulation of immune system process 6 5.22 0.02 CD47, C3, KLRE1, TRAF6, CD1D1, DDAH1
GOTERM_BP_2 GO:0002252 ~ immune effector process 4 3.48 0.05 CD47, NCF1, C3, DDAH1
GOTERM_BP_3 GO:0002252 ~ immune effector process 4 3.48 0.05 CD47, NCF1, C3, DDAH1
GOTERM_BP_4 GO:0006968 ~ cellular defense response 2 1.74 0.05 NCF1, DDAH1
GOTERM_BP_1 GO:0022610 ~ biological adhesion 7 6.09 0.09 CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61
GOTERM_BP_2 GO:0007155 ~ cell adhesion 7 6.09 0.09 CD47, SDC1, RET, CNTNAP1, COL5A3, BTBD9, CYR61
GOTERM_BP_1 GO:0048511 ~ rhythmic process 7 6.09 0.00 ALDH1A1, NPAS2, JUND, PER2, TEF, CHRNA7, ARNTL
GOTERM_BP_2 GO:0007623 ~ circadian rhythm 4 3.48 0.01 NPAS2, JUND, PER2, ARNTL