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Table 2 Down-regulated genes (>3.0-fold down-regulation)

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Gene function Description (gene symbol) Acc. no. AVE log2 SD (LOG) P value (Corr) Fold change SD
Metabolism Transglutaminase 1 (Tgm1) NM_031659 −1.98 0.55 0.0002 −3.93 1.87
CARBONIC anhydrase 6 (Car6) NM_001134841 −2.03 0.76 0.0002 −4.08 2.61
Phenazine biosynthesis-like protein domain containing 1 (Pbld1) NM_138530 −2.14 0.68 0.0001 −4.41 2.60
Coproporphyrinogen oxidase (Cpox) NM_001037095 −2.32 0.45 0.0001 −4.98 2.06
Prolyl 4-hydroxylase, alpha polypeptide III (P4ha3) XM_006229769 −2.36 0.38 0.0001 −5.13 1.68
Signal transduction, regulation of transcription cAMP responsive element binding protein 5 (Creb5) XM_006236505 −1.62 0.52 0.0001 −3.07 1.26
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3) NM_001024767 −1.74 0.65 0.0006 −3.35 1.95
Hypermethylated in cancer 1 (Hic1) NM_001107021 −1.83 0.70 0.0019 −3.55 2.10
Rho guanine nucleotide exchange factor (GEF) 5 (Arhgef5) XM_006224892 −1.96 0.47 0.0001 −3.89 1.45
Thyroid hormone responsive (Thrsp) NM_012703 −2.28 0.98 0.0020 −4.86 5.18
Cellular retinoic acid binding protein 2 (Crabp2) NM_017244 −2.32 0.50 0.0001 −4.98 2.42
A kinase (PRKA) anchor protein 3 (Akap3) NM_001005557 −2.68 0.35 0.0000 −6.39 1.90
Uroplakin 1B (Upk1b) NM_001024253 −3.69 0.69 0.0001 −12.89 7.94
Receptors, ion channels Interleukin 22 receptor, alpha 2 (Il22ra2) NM_001003404 −1.62 0.93 0.0064 −3.07 2.78
Neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcript variant 3 NM_019248 −1.64 0.45 0.0005 −3.12 1.18
Adrenoceptor alpha 1D (Adra1d) NM_024483 −1.69 0.37 0.0007 −3.23 1.09
Lysophosphatidic acid receptor 1 (Lpar1) NM_053936 −1.83 0.51 0.0000 −3.55 1.50
Prostaglandin F receptor (Ptgfr) NM_013115 −1.87 0.44 0.0000 −3.65 1.40
Solute carrier family 4 (anion exchanger), member 1 (Slc4a1) NM_012651 −2.39 0.22 0.0000 −5.23 0.94
Sarcolipin (Sln) NM_001013247 −3.00 1.41 0.0028 −8.03 15.41
ATPase, H + transporting, lysosomal accessory protein 1-like (Atp6ap1 l) NM_001191843 −3.59 0.31 0.0000 −12.06 3.25
Membrane proteins Sarcolipin (Sln) CK841541 −2.51 1.08 0.0019 −5.68 7.12
Structural protein, cell adhesion Collagen, type V, alpha 3 (Col5a3) NM_021760 −1.78 0.59 0.0001 −3.43 1.46
Contactin associated protein 1 (Cntnap1) NM_032061 −2.03 0.34 0.0000 −4.09 1.11
Myosin binding protein H-like (Mybphl) NM_001014042 −2.82 1.17 0.0011 −7.08 8.55
Myosin, light chain 7, regulatory (Myl7) NM_001106017 −3.37 1.66 0.0030 −10.34 20.29
Mesothelin (Msln) NM_031658 −4.46 1.44 0.0010 −22.03 31.18
Cell growth and differentiation Ret proto-oncogene (Ret), transcript variant 1 NM_012643 −1.64 0.44 0.0000 −3.11 1.15
Endothelial cell-specific molecule 1 (Esm1) NM_022604 −2.28 0.39 0.0000 −4.85 1.57
Neuronatin (Nnat), transcript variant 1 NM_053601 −2.34 1.34 0.0119 −5.06 10.47
Endothelial cell-specific molecule 1 (Esm1) NM_022604 −2.36 0.40 0.0000 −5.13 1.64
Epiphycan (Epyc) NM_001108088 −2.36 1.37 0.0083 −5.14 7.64
Cyclin G1 (Ccng1) NM_012923 −3.36 0.21 0.0000 −10.29 1.82
Tripartite motif-containing 16 (Trim16) NM_001135033 −6.33 0.41 0.0000 −80.63 28.07
Immune response Regenerating islet-derived 3 beta (Reg3b) NM_053289 −1.81 1.34 0.0300 −3.52 5.83
Inducible T-cell co-stimulator ligand (Icoslg) XM_006223832 −1.92 0.37 0.0000 −3.79 1.16
Complement component 4A (Rodgers blood group) (C4a) NM_031504 −2.25 0.75 0.0002 −4.77 3.07
Chemokine (C-X-C motif) ligand 13 (Cxcl13) NM_001017496 −2.48 0.78 0.0003 −5.57 4.38
Similar to immunoglobulin superfamily, member 7 (RGD1559482), NM_001168285 −2.54 0.43 0.0000 −5.83 2.19
CD1d1 molecule (Cd1d1) NM_017079 −2.64 0.53 0.0000 −6.21 2.67
Chymase 1, mast cell (Cma1) NM_013092 −3.95 0.45 0.0000 −15.40 6.26
Transport Retinol binding protein 4, plasma (Rbp4) NM_013162 −2.09 1.20 0.0131 −4.27 7.22
Hormones Inhibin alpha (Inha) NM_012590 −1.79 0.56 0.0020 −3.45 1.80
Others Protein Arhgef5 (Source:UniProtKB/TrEMBL;Acc:E9PT59) XM_006224892 −1.62 0.54 0.0002 −3.07 1.33
Hypothetical protein LOC100302372 (LOC100302372) NM_001162897 −1.63 0.57 0.0004 −3.10 1.69
(F344/Crj)rearranged mRNA for T-cell receptor gamma chain (1483 bp) Z27087 −1.65 0.71 0.0045 −3.13 1.94
Similar to RIKEN cDNA 1700001E04 (LOC367428), mRNA (XM_346135) XM_346135 −1.65 0.25 0.0000 −3.14 0.68
BTB (POZ) domain containing 9 (Btbd9) XM_006256185 −1.66 0.30 0.0000 −3.15 0.73
Q99NG8_RAT (Q99NG8) T:G mismatch thymine glycosylase   −1.67 0.44 0.0001 −3.17 1.24
Hypothetical protein LOC689316 (LOC689316) XR_086061 −1.68 0.39 0.0000 −3.21 1.02
Uroplakin 3B-like (Upk3bl) NM_001109020 −1.69 0.37 0.0013 −3.22 1.04
NEUU_MOUSE (Q9QXK8) Neuromedin U-23 precursor (NmU-23)   −1.71 0.43 0.0000 −3.28 1.10
Ripply transcriptional repressor 2 (Ripply2) XM_001064780 −1.73 0.44 0.0000 −3.31 1.22
Uncharacterized LOC100912446 (LOC100912446) FQ221838 −1.73 0.64 0.0005 −3.33 1.76
Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2) (LOC685619) XM_002729250 −1.75 0.32 0.0000 −3.37 0.84
Erythrocyte membrane protein band 4.1-like 3 (Epb41l3) NM_053927 −1.77 0.90 0.0057 −3.41 2.69
Uncharacterized LOC102556259 (LOC102556259) XR_355327 −1.77 0.38 0.0001 −3.42 1.22
EF-hand domain family, member D1 (Efhd1) NM_001109310 −1.81 0.46 0.0000 −3.50 1.45
Zinc finger and BTB domain containing 20 (Zbtb20) XM_006248302 −1.87 0.48 0.0000 −3.67 1.69
Suppressor of glucose, autophagy associated 1 (Soga1) XM_001067659 −1.89 0.66 0.0001 −3.72 2.23
Protein RGD1562667 XM_221091 −1.91 0.45 0.0000 −3.75 1.49
Uncharacterized protein (Source:UniProtKB/TrEMBL;Acc:F1LSJ2) (ENSRNOT00000035259) XM_001061015 −1.93 0.61 0.0001 −3.80 2.07
Uncharacterized LOC102546664 (LOC102546664) XR_342060 −1.95 0.18 0.0000 −3.87 0.58
Protein Rsf1 (Source:UniProtKB/TrEMBL;Acc:D3ZGQ8) XM_218939 −1.95 1.05 0.0109 −3.87 2.89
Nucleosome assembly protein 1-like 5 (Nap1l5) NM_001044293 −1.97 1.04 0.0039 −3.92 3.86
Methyltransferase like 2B (Mettl2b) NM_001108839 −2.07 0.40 0.0000 −4.20 1.36
Similar to immunoreceptor Ly49si3 (LOC690097) XM_003753951 −2.19 0.50 0.0001 −4.55 2.20
Neuronal PAS domain protein 2 (Npas2) NM_001108214 −2.23 0.47 0.0000 −4.69 1.73
FM089532 etnofat cDNA clone etnofatP0014D18 5′, mRNA sequence FM089532 −2.40 0.36 0.0001 −5.28 1.54
Chordin-like 1 (Chrdl1) NM_199502 −2.46 0.27 0.0000 −5.51 1.30
Uncharacterized LOC102557390 (LOC102557390) XR_348511 −2.54 0.48 0.0000 −5.82 2.30
Q7TQ12_RAT (Q7TQ12) Aa1114   −2.62 0.32 0.0000 −6.14 1.69
TL0ACA45YL24 mRNA sequence FQ215947 −2.65 0.48 0.0000 −6.27 2.81
Aryl hydrocarbon receptor nuclear translocator-like (Arntl) NM_024362 −2.75 0.54 0.0000 −6.75 2.85
Similar to RIKEN cDNA 1500015O10 (RGD1305645) NM_001271051 −2.84 0.88 0.0003 −7.17 7.06
Uncharacterized LOC100911508 (LOC100911508) XR_145872 −2.86 0.30 0.0000 −7.25 1.86
TL0ACA40YB18 mRNA sequence. FQ216879 −2.99 1.21 0.0012 −7.94 9.21
Family with sequence similarity 216, member B (Fam216b) XM_003751515 −3.04 0.89 0.0002 −8.25 6.41
SARCO_MOUSE (Q9CQD6) Sarcolipin, complete (TC628765) AW918768 −3.06 1.35 0.0020 −8.33 14.57
Endogenous retrovirus mRNA AY212271 −3.51 1.47 0.0015 −11.38 17.10
Uncharacterized LOC102552170 (LOC102552170) XM_006224493 −4.01 0.40 0.0000 −16.09 5.74
O89816_9GAMR (O89816) Envelope glycoprotein   −4.04 0.99 0.0001 −16.49 15.56
Rat PRRHIS8 mRNA for ribosomal protein S8. (X56846) X56846 −4.14 0.73 0.0000 −17.63 12.05
Elongator protein 3/MiaB/NifB   −4.21 0.37 0.0000 −18.51 5.56
Endogenous retrovirus mRNA AY212271 −4.21 1.48 0.0006 −18.52 28.67
Similar to 60S ribosomal protein L19 (LOC316856) XM_229366 −4.46 0.84 0.0000 −22.05 16.63
Uncharacterized LOC102554872 (LOC102554872) XR_348916 −4.86 0.35 0.0000 −29.02 8.07
WDNM1 homolog (LOC360228) NM_001003706 −5.14 1.80 0.0013 −35.24 76.86