Skip to main content

Table 2 Down-regulated genes (>3.0-fold down-regulation)

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Gene function

Description (gene symbol)

Acc. no.

AVE log2

SD (LOG)

P value (Corr)

Fold change

SD

Metabolism

Transglutaminase 1 (Tgm1)

NM_031659

−1.98

0.55

0.0002

−3.93

1.87

CARBONIC anhydrase 6 (Car6)

NM_001134841

−2.03

0.76

0.0002

−4.08

2.61

Phenazine biosynthesis-like protein domain containing 1 (Pbld1)

NM_138530

−2.14

0.68

0.0001

−4.41

2.60

Coproporphyrinogen oxidase (Cpox)

NM_001037095

−2.32

0.45

0.0001

−4.98

2.06

Prolyl 4-hydroxylase, alpha polypeptide III (P4ha3)

XM_006229769

−2.36

0.38

0.0001

−5.13

1.68

Signal transduction, regulation of transcription

cAMP responsive element binding protein 5 (Creb5)

XM_006236505

−1.62

0.52

0.0001

−3.07

1.26

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3)

NM_001024767

−1.74

0.65

0.0006

−3.35

1.95

Hypermethylated in cancer 1 (Hic1)

NM_001107021

−1.83

0.70

0.0019

−3.55

2.10

Rho guanine nucleotide exchange factor (GEF) 5 (Arhgef5)

XM_006224892

−1.96

0.47

0.0001

−3.89

1.45

Thyroid hormone responsive (Thrsp)

NM_012703

−2.28

0.98

0.0020

−4.86

5.18

Cellular retinoic acid binding protein 2 (Crabp2)

NM_017244

−2.32

0.50

0.0001

−4.98

2.42

A kinase (PRKA) anchor protein 3 (Akap3)

NM_001005557

−2.68

0.35

0.0000

−6.39

1.90

Uroplakin 1B (Upk1b)

NM_001024253

−3.69

0.69

0.0001

−12.89

7.94

Receptors, ion channels

Interleukin 22 receptor, alpha 2 (Il22ra2)

NM_001003404

−1.62

0.93

0.0064

−3.07

2.78

Neurotrophic tyrosine kinase, receptor, type 3 (Ntrk3), transcript variant 3

NM_019248

−1.64

0.45

0.0005

−3.12

1.18

Adrenoceptor alpha 1D (Adra1d)

NM_024483

−1.69

0.37

0.0007

−3.23

1.09

Lysophosphatidic acid receptor 1 (Lpar1)

NM_053936

−1.83

0.51

0.0000

−3.55

1.50

Prostaglandin F receptor (Ptgfr)

NM_013115

−1.87

0.44

0.0000

−3.65

1.40

Solute carrier family 4 (anion exchanger), member 1 (Slc4a1)

NM_012651

−2.39

0.22

0.0000

−5.23

0.94

Sarcolipin (Sln)

NM_001013247

−3.00

1.41

0.0028

−8.03

15.41

ATPase, H + transporting, lysosomal accessory protein 1-like (Atp6ap1 l)

NM_001191843

−3.59

0.31

0.0000

−12.06

3.25

Membrane proteins

Sarcolipin (Sln)

CK841541

−2.51

1.08

0.0019

−5.68

7.12

Structural protein, cell adhesion

Collagen, type V, alpha 3 (Col5a3)

NM_021760

−1.78

0.59

0.0001

−3.43

1.46

Contactin associated protein 1 (Cntnap1)

NM_032061

−2.03

0.34

0.0000

−4.09

1.11

Myosin binding protein H-like (Mybphl)

NM_001014042

−2.82

1.17

0.0011

−7.08

8.55

Myosin, light chain 7, regulatory (Myl7)

NM_001106017

−3.37

1.66

0.0030

−10.34

20.29

Mesothelin (Msln)

NM_031658

−4.46

1.44

0.0010

−22.03

31.18

Cell growth and differentiation

Ret proto-oncogene (Ret), transcript variant 1

NM_012643

−1.64

0.44

0.0000

−3.11

1.15

Endothelial cell-specific molecule 1 (Esm1)

NM_022604

−2.28

0.39

0.0000

−4.85

1.57

Neuronatin (Nnat), transcript variant 1

NM_053601

−2.34

1.34

0.0119

−5.06

10.47

Endothelial cell-specific molecule 1 (Esm1)

NM_022604

−2.36

0.40

0.0000

−5.13

1.64

Epiphycan (Epyc)

NM_001108088

−2.36

1.37

0.0083

−5.14

7.64

Cyclin G1 (Ccng1)

NM_012923

−3.36

0.21

0.0000

−10.29

1.82

Tripartite motif-containing 16 (Trim16)

NM_001135033

−6.33

0.41

0.0000

−80.63

28.07

Immune response

Regenerating islet-derived 3 beta (Reg3b)

NM_053289

−1.81

1.34

0.0300

−3.52

5.83

Inducible T-cell co-stimulator ligand (Icoslg)

XM_006223832

−1.92

0.37

0.0000

−3.79

1.16

Complement component 4A (Rodgers blood group) (C4a)

NM_031504

−2.25

0.75

0.0002

−4.77

3.07

Chemokine (C-X-C motif) ligand 13 (Cxcl13)

NM_001017496

−2.48

0.78

0.0003

−5.57

4.38

Similar to immunoglobulin superfamily, member 7 (RGD1559482),

NM_001168285

−2.54

0.43

0.0000

−5.83

2.19

CD1d1 molecule (Cd1d1)

NM_017079

−2.64

0.53

0.0000

−6.21

2.67

Chymase 1, mast cell (Cma1)

NM_013092

−3.95

0.45

0.0000

−15.40

6.26

Transport

Retinol binding protein 4, plasma (Rbp4)

NM_013162

−2.09

1.20

0.0131

−4.27

7.22

Hormones

Inhibin alpha (Inha)

NM_012590

−1.79

0.56

0.0020

−3.45

1.80

Others

Protein Arhgef5 (Source:UniProtKB/TrEMBL;Acc:E9PT59)

XM_006224892

−1.62

0.54

0.0002

−3.07

1.33

Hypothetical protein LOC100302372 (LOC100302372)

NM_001162897

−1.63

0.57

0.0004

−3.10

1.69

(F344/Crj)rearranged mRNA for T-cell receptor gamma chain (1483 bp)

Z27087

−1.65

0.71

0.0045

−3.13

1.94

Similar to RIKEN cDNA 1700001E04 (LOC367428), mRNA (XM_346135)

XM_346135

−1.65

0.25

0.0000

−3.14

0.68

BTB (POZ) domain containing 9 (Btbd9)

XM_006256185

−1.66

0.30

0.0000

−3.15

0.73

Q99NG8_RAT (Q99NG8) T:G mismatch thymine glycosylase

 

−1.67

0.44

0.0001

−3.17

1.24

Hypothetical protein LOC689316 (LOC689316)

XR_086061

−1.68

0.39

0.0000

−3.21

1.02

Uroplakin 3B-like (Upk3bl)

NM_001109020

−1.69

0.37

0.0013

−3.22

1.04

NEUU_MOUSE (Q9QXK8) Neuromedin U-23 precursor (NmU-23)

 

−1.71

0.43

0.0000

−3.28

1.10

Ripply transcriptional repressor 2 (Ripply2)

XM_001064780

−1.73

0.44

0.0000

−3.31

1.22

Uncharacterized LOC100912446 (LOC100912446)

FQ221838

−1.73

0.64

0.0005

−3.33

1.76

Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2) (LOC685619)

XM_002729250

−1.75

0.32

0.0000

−3.37

0.84

Erythrocyte membrane protein band 4.1-like 3 (Epb41l3)

NM_053927

−1.77

0.90

0.0057

−3.41

2.69

Uncharacterized LOC102556259 (LOC102556259)

XR_355327

−1.77

0.38

0.0001

−3.42

1.22

EF-hand domain family, member D1 (Efhd1)

NM_001109310

−1.81

0.46

0.0000

−3.50

1.45

Zinc finger and BTB domain containing 20 (Zbtb20)

XM_006248302

−1.87

0.48

0.0000

−3.67

1.69

Suppressor of glucose, autophagy associated 1 (Soga1)

XM_001067659

−1.89

0.66

0.0001

−3.72

2.23

Protein RGD1562667

XM_221091

−1.91

0.45

0.0000

−3.75

1.49

Uncharacterized protein (Source:UniProtKB/TrEMBL;Acc:F1LSJ2) (ENSRNOT00000035259)

XM_001061015

−1.93

0.61

0.0001

−3.80

2.07

Uncharacterized LOC102546664 (LOC102546664)

XR_342060

−1.95

0.18

0.0000

−3.87

0.58

Protein Rsf1 (Source:UniProtKB/TrEMBL;Acc:D3ZGQ8)

XM_218939

−1.95

1.05

0.0109

−3.87

2.89

Nucleosome assembly protein 1-like 5 (Nap1l5)

NM_001044293

−1.97

1.04

0.0039

−3.92

3.86

Methyltransferase like 2B (Mettl2b)

NM_001108839

−2.07

0.40

0.0000

−4.20

1.36

Similar to immunoreceptor Ly49si3 (LOC690097)

XM_003753951

−2.19

0.50

0.0001

−4.55

2.20

Neuronal PAS domain protein 2 (Npas2)

NM_001108214

−2.23

0.47

0.0000

−4.69

1.73

FM089532 etnofat cDNA clone etnofatP0014D18 5′, mRNA sequence

FM089532

−2.40

0.36

0.0001

−5.28

1.54

Chordin-like 1 (Chrdl1)

NM_199502

−2.46

0.27

0.0000

−5.51

1.30

Uncharacterized LOC102557390 (LOC102557390)

XR_348511

−2.54

0.48

0.0000

−5.82

2.30

Q7TQ12_RAT (Q7TQ12) Aa1114

 

−2.62

0.32

0.0000

−6.14

1.69

TL0ACA45YL24 mRNA sequence

FQ215947

−2.65

0.48

0.0000

−6.27

2.81

Aryl hydrocarbon receptor nuclear translocator-like (Arntl)

NM_024362

−2.75

0.54

0.0000

−6.75

2.85

Similar to RIKEN cDNA 1500015O10 (RGD1305645)

NM_001271051

−2.84

0.88

0.0003

−7.17

7.06

Uncharacterized LOC100911508 (LOC100911508)

XR_145872

−2.86

0.30

0.0000

−7.25

1.86

TL0ACA40YB18 mRNA sequence.

FQ216879

−2.99

1.21

0.0012

−7.94

9.21

Family with sequence similarity 216, member B (Fam216b)

XM_003751515

−3.04

0.89

0.0002

−8.25

6.41

SARCO_MOUSE (Q9CQD6) Sarcolipin, complete (TC628765)

AW918768

−3.06

1.35

0.0020

−8.33

14.57

Endogenous retrovirus mRNA

AY212271

−3.51

1.47

0.0015

−11.38

17.10

Uncharacterized LOC102552170 (LOC102552170)

XM_006224493

−4.01

0.40

0.0000

−16.09

5.74

O89816_9GAMR (O89816) Envelope glycoprotein

 

−4.04

0.99

0.0001

−16.49

15.56

Rat PRRHIS8 mRNA for ribosomal protein S8. (X56846)

X56846

−4.14

0.73

0.0000

−17.63

12.05

Elongator protein 3/MiaB/NifB

 

−4.21

0.37

0.0000

−18.51

5.56

Endogenous retrovirus mRNA

AY212271

−4.21

1.48

0.0006

−18.52

28.67

Similar to 60S ribosomal protein L19 (LOC316856)

XM_229366

−4.46

0.84

0.0000

−22.05

16.63

Uncharacterized LOC102554872 (LOC102554872)

XR_348916

−4.86

0.35

0.0000

−29.02

8.07

WDNM1 homolog (LOC360228)

NM_001003706

−5.14

1.80

0.0013

−35.24

76.86