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Table 1 Up-regulated genes (>3.0-fold up-regulation)

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Gene function Description (gene symbol) Acc. no. AVE log2 SD (LOG) P value (Corr) Fold change SD
Metabolism Abhydrolase domain containing 17C (Abhd17c) NM_001100736 2.79 0.39 0.00 6.96 1.72
Alcohol dehydrogenase 1 (class I) (Adh1) NM_019286 2.43 0.99 0.00 5.38 2.78
Retinol saturase (all trans retinol 13,14 reductase) (Retsat) NM_145084 2.17 1.14 0.01 4.50 3.61
Diacylglycerol kinase, beta (Dgkb) NM_019304 2.07 0.34 0.00 4.21 0.82
Kallikrein 1-related peptidase C3 (Klk1c3) NM_001271315 1.92 0.45 0.00 3.79 1.07
Aldo–keto reductase family 1, member B10 (aldose reductase) (Akr1b10) NM_001013084 1.91 0.44 0.00 3.76 1.05
Adenosine monophosphate deaminase 1 (Ampd1) NM_138876 1.61 0.71 0.00 3.06 1.56
Signal transduction, regulation of transcription Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7) NM_001009353 2.23 0.29 0.00 4.68 0.88
Protein tyrosine phosphatase, non-receptor type 13 (Ptpn13) NM_001100789 2.13 1.06 0.00 4.38 2.18
Ephrin A2 (Efna2) NM_001168670 1.77 0.31 0.00 3.41 0.60
Crystallin, mu (Crym) NM_053955 1.76 0.39 0.00 3.38 0.78
Cd47 molecule (Cd47) NM_019195 1.74 0.26 0.00 3.34 0.51
Calsyntenin 2 (Clstn2) NM_134377 1.63 0.65 0.00 3.09 1.41
Ring finger protein 187 (Rnf187) NM_001164264 1.61 0.34 0.00 3.06 0.63
Receptors, ion channels Potassium voltage-gated channel, Isk-related family, member 1 (Kcne1) NM_012973 2.72 0.82 0.00 6.57 4.07
ATPase, H+ transporting, lysosomal V1 subunit G2 (Atp6v1g2) NM_212490 2.53 0.60 0.00 5.77 2.02
Cholinergic receptor, nicotinic, alpha 7 (neuronal) (Chrna7) S53987 1.79 0.31 0.00 3.45 0.63
ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2) NM_012508 1.71 0.50 0.00 3.27 0.91
Membrane proteins Peroxisomal membrane protein 4 (Pxmp4) NM_172223 2.52 0.21 0.00 5.73 0.74
Cell growth and differentiation Transcription elongation factor A (SII)-like 7 (Tceal7) NM_001109401 1.86 0.84 0.00 3.63 1.88
Jun D proto-oncogene (Jund) NM_138875 1.71 0.29 0.00 3.28 0.60
Immune response RT1 class Ib, locus T18 (RT1-T18) NM_001002821 2.31 0.77 0.00 4.95 2.21
2′-5′ oligoadenylate synthetase 1A (Oas1a) NM_138913 1.98 0.86 0.00 3.94 2.50
Transport ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2) NM_012508 1.78 0.41 0.00 3.44 0.77
Solute carrier family 16 (monocarboxylate transporter), member 7 (Slc16a7) NM_017302 1.64 0.38 0.00 3.11 0.69
Others Guanylate binding protein 1, interferon-inducible (gbp1) XM_006224278 4.80 0.49 0.00 27.84 8.96
Uncharacterized LOC102549588 XR_362031 4.69 0.54 0.00 25.85 8.31
Twin-arginine translocation pathway signal   4.52 0.58 0.00 23.01 9.81
TL0ADA29YA08 mRNA sequence FQ222105 3.27 0.42 0.00 9.64 2.34
Similar to ribosomal protein L6 (LOC366145) XM_345411 2.94 0.59 0.00 7.70 3.03
Mitochondrial ribosomal protein S10 (Mrps10) NM_001008859 2.86 1.24 0.00 7.28 4.07
Cd300 molecule-like family member G (Cd300lg) XM_003750936 2.61 0.68 0.00 6.10 2.99
MRNA decapping enzyme   2.32 0.35 0.00 4.99 1.11
Transmembrane emp24 domain-containing protein 5 precursor   2.14 0.28 0.00 4.41 0.72
Macrophage activation 2 like (Mpa2 l) XM_006221662 2.10 1.05 0.00 4.30 3.00
Similar to interferon-inducible GTPase (RGD1309362) NM_001024884 2.02 0.84 0.00 4.06 2.65
Myc-like oncogene, s-myc protein (Mycs) NM_021837 2.00 0.80 0.00 4.00 1.64
Uncharacterized LOC102556738 XR_340771 1.96 0.44 0.00 3.89 1.10
Nuclear casein kinase and cyclin-dependent kinase substrate 1 (Nucks1) XM_006249797 1.96 0.34 0.00 3.89 0.74
Transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) (Tle6) XM_006241027 1.95 0.43 0.00 3.87 1.10
Transmembrane protein 132C (Tmem132c) XM_002724836 1.91 0.45 0.00 3.75 1.09
CWC25 spliceosome-associated protein homolog (S. cerevisiae) (Cwc25) NM_001108295 1.82 0.76 0.00 3.52 1.65
Contactin associated protein-like 2 (Cntnap2) XM_006236412 1.79 0.39 0.00 3.47 0.84
Anaphase promoting complex subunit 10 (Anapc10) XM_006255406 1.77 1.29 0.03 3.41 4.41
Deoxycytidine triphosphate deaminase   1.73 0.35 0.00 3.32 0.74
Hypothetical protein LOC500028 NM_001047954 1.65 0.38 0.00 3.13 0.66
RNA binding motif protein 44 (Rbm44) XM_001066845 1.64 0.46 0.00 3.12 0.87
Trichorhinophalangeal syndrome I (Trps1) XM_006241626 1.62 0.39 0.00 3.08 0.69
Excision repair cross-complementing rodent repair deficiency, complementation group 8 (Ercc8) NM_001107650 1.60 0.27 0.00 3.03 0.49
Uncharacterized LOC100912569 XR_348427 1.59 0.82 0.01 3.02 1.80