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Table 1 Up-regulated genes (>3.0-fold up-regulation)

From: Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats

Gene function

Description (gene symbol)

Acc. no.

AVE log2

SD (LOG)

P value (Corr)

Fold change

SD

Metabolism

Abhydrolase domain containing 17C (Abhd17c)

NM_001100736

2.79

0.39

0.00

6.96

1.72

Alcohol dehydrogenase 1 (class I) (Adh1)

NM_019286

2.43

0.99

0.00

5.38

2.78

Retinol saturase (all trans retinol 13,14 reductase) (Retsat)

NM_145084

2.17

1.14

0.01

4.50

3.61

Diacylglycerol kinase, beta (Dgkb)

NM_019304

2.07

0.34

0.00

4.21

0.82

Kallikrein 1-related peptidase C3 (Klk1c3)

NM_001271315

1.92

0.45

0.00

3.79

1.07

Aldo–keto reductase family 1, member B10 (aldose reductase) (Akr1b10)

NM_001013084

1.91

0.44

0.00

3.76

1.05

Adenosine monophosphate deaminase 1 (Ampd1)

NM_138876

1.61

0.71

0.00

3.06

1.56

Signal transduction, regulation of transcription

Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) (Pla2g7)

NM_001009353

2.23

0.29

0.00

4.68

0.88

Protein tyrosine phosphatase, non-receptor type 13 (Ptpn13)

NM_001100789

2.13

1.06

0.00

4.38

2.18

Ephrin A2 (Efna2)

NM_001168670

1.77

0.31

0.00

3.41

0.60

Crystallin, mu (Crym)

NM_053955

1.76

0.39

0.00

3.38

0.78

Cd47 molecule (Cd47)

NM_019195

1.74

0.26

0.00

3.34

0.51

Calsyntenin 2 (Clstn2)

NM_134377

1.63

0.65

0.00

3.09

1.41

Ring finger protein 187 (Rnf187)

NM_001164264

1.61

0.34

0.00

3.06

0.63

Receptors, ion channels

Potassium voltage-gated channel, Isk-related family, member 1 (Kcne1)

NM_012973

2.72

0.82

0.00

6.57

4.07

ATPase, H+ transporting, lysosomal V1 subunit G2 (Atp6v1g2)

NM_212490

2.53

0.60

0.00

5.77

2.02

Cholinergic receptor, nicotinic, alpha 7 (neuronal) (Chrna7)

S53987

1.79

0.31

0.00

3.45

0.63

ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2)

NM_012508

1.71

0.50

0.00

3.27

0.91

Membrane proteins

Peroxisomal membrane protein 4 (Pxmp4)

NM_172223

2.52

0.21

0.00

5.73

0.74

Cell growth and differentiation

Transcription elongation factor A (SII)-like 7 (Tceal7)

NM_001109401

1.86

0.84

0.00

3.63

1.88

Jun D proto-oncogene (Jund)

NM_138875

1.71

0.29

0.00

3.28

0.60

Immune response

RT1 class Ib, locus T18 (RT1-T18)

NM_001002821

2.31

0.77

0.00

4.95

2.21

2′-5′ oligoadenylate synthetase 1A (Oas1a)

NM_138913

1.98

0.86

0.00

3.94

2.50

Transport

ATPase, Ca++ transporting, plasma membrane 2 (Atp2b2)

NM_012508

1.78

0.41

0.00

3.44

0.77

Solute carrier family 16 (monocarboxylate transporter), member 7 (Slc16a7)

NM_017302

1.64

0.38

0.00

3.11

0.69

Others

Guanylate binding protein 1, interferon-inducible (gbp1)

XM_006224278

4.80

0.49

0.00

27.84

8.96

Uncharacterized LOC102549588

XR_362031

4.69

0.54

0.00

25.85

8.31

Twin-arginine translocation pathway signal

 

4.52

0.58

0.00

23.01

9.81

TL0ADA29YA08 mRNA sequence

FQ222105

3.27

0.42

0.00

9.64

2.34

Similar to ribosomal protein L6 (LOC366145)

XM_345411

2.94

0.59

0.00

7.70

3.03

Mitochondrial ribosomal protein S10 (Mrps10)

NM_001008859

2.86

1.24

0.00

7.28

4.07

Cd300 molecule-like family member G (Cd300lg)

XM_003750936

2.61

0.68

0.00

6.10

2.99

MRNA decapping enzyme

 

2.32

0.35

0.00

4.99

1.11

Transmembrane emp24 domain-containing protein 5 precursor

 

2.14

0.28

0.00

4.41

0.72

Macrophage activation 2 like (Mpa2 l)

XM_006221662

2.10

1.05

0.00

4.30

3.00

Similar to interferon-inducible GTPase (RGD1309362)

NM_001024884

2.02

0.84

0.00

4.06

2.65

Myc-like oncogene, s-myc protein (Mycs)

NM_021837

2.00

0.80

0.00

4.00

1.64

Uncharacterized LOC102556738

XR_340771

1.96

0.44

0.00

3.89

1.10

Nuclear casein kinase and cyclin-dependent kinase substrate 1 (Nucks1)

XM_006249797

1.96

0.34

0.00

3.89

0.74

Transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila) (Tle6)

XM_006241027

1.95

0.43

0.00

3.87

1.10

Transmembrane protein 132C (Tmem132c)

XM_002724836

1.91

0.45

0.00

3.75

1.09

CWC25 spliceosome-associated protein homolog (S. cerevisiae) (Cwc25)

NM_001108295

1.82

0.76

0.00

3.52

1.65

Contactin associated protein-like 2 (Cntnap2)

XM_006236412

1.79

0.39

0.00

3.47

0.84

Anaphase promoting complex subunit 10 (Anapc10)

XM_006255406

1.77

1.29

0.03

3.41

4.41

Deoxycytidine triphosphate deaminase

 

1.73

0.35

0.00

3.32

0.74

Hypothetical protein LOC500028

NM_001047954

1.65

0.38

0.00

3.13

0.66

RNA binding motif protein 44 (Rbm44)

XM_001066845

1.64

0.46

0.00

3.12

0.87

Trichorhinophalangeal syndrome I (Trps1)

XM_006241626

1.62

0.39

0.00

3.08

0.69

Excision repair cross-complementing rodent repair deficiency, complementation group 8 (Ercc8)

NM_001107650

1.60

0.27

0.00

3.03

0.49

Uncharacterized LOC100912569

XR_348427

1.59

0.82

0.01

3.02

1.80