Fig. 3From: Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and designREFORM trial hypothesis. The figure above explains the hypothesis of the REFORM trial where reduction in pre and afterload as well as improvement in exercise capacity and weight loss will all contribute to improvement in heart failure. These features will be measured by cardiac MRI, CPEX, 6MWT and BCA to determine their exact contribution to cardiac function. CPEX cardio-pulmonary exercise test; 6MWT 6 min walk test; BCA body composition analysis; V02 Max Maximum oxygen consumption; Ve minute ventilation; VC02 carbon dioxide productionBack to article page