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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design

Fig. 1

Normal renal tubular resorption of glucose. The figure above depicts the physiological resorption of glucose in the PCT of the nephron. SGLT2 co-transporters located at the S1 and S2 segments of the PCT are responsible for 90 % of the resorbed glucose, whereas SGLT1 co-transporters remove the remainder in the S3 segment. The diagram also identifies the site at which SGLT2 inhibitors act. PCT proximal convoluted tubules

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Cardiovascular Diabetology

ISSN: 1475-2840