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Table 3 Change in parameters of global systolic function, and ischemic regional segments in demand ischemia protocol

From: Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

 

GLP-1 only

GLP-1 glibenclamide

p value

Ejection fraction (%)

 Baseline

62.4 ± 8.4

63.1 ± 8.5

0.45

 Peak stress

74.6 ± 6.4

74.0 ± 8.1

0.76

 Recovery

61.9 ± 5.7

61.4 ± 5.6

0.74

MASV, cm/s

 Baseline

5.47 ± 1.79

5.51 ± 1.78

0.82

 Peak stress

11.40 ± 2.69

11.06 ± 2.80

0.24

 Recovery

5.70 ± 1.99

5.62 ± 1.75

0.51

Peak systolic velocity (Vs), cm/s

 Baseline

3.76 ± 1.89

3.92 ± 2.07

0.38

 Peak stress

9.86 ± 3.08

9.59 ± 2.81

0.18

 Recovery

3.95 ± 1.95

4.04 ± 1.56

0.98

Strain index (SI), %

 Baseline

−15.3 ± 5.83

−15.1 ± 5.30

0.68

 Peak stress

−15.5 ± 5.52

−15.6 ± 6.09

0.92

 Recovery

−14.8 ± 5.35

−15.3 ± 6.21

0.48

Strain rate index (SRI), s-1

 Baseline

−1.19 ± 0.74

−1.25 ± 0.51

0.29

 Peak stress

−2.68 ± 1.69

−2.79 ± 1.17

0.65

 Recovery

−1.24 ± 0.92

−1.25 ± 0.69

0.71