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Table 2 Change in parameters of systolic and diastolic function (compared to BL1) in supply ischemia protocol

From: Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

 

Baseline 1 (BL1)

Balloon occlusion 1 (BO1)

Baseline 2 (BL2)

Balloon occlusion 2 (BO2)

%

Δ %

p value*

Δ %

p value*

Δ %

p value*

dP/dtmax

 Control

100

−15.4 ± 13.6

0.012

−11.5 ± 10.0

<0.01

−25.7 ± 9.6

<0.001

 GLP-1 only

100

−16.1 ± 10.2

<0.01

−0.3 ± 6.8

0.92

−12.8 ± 10.5

0.011

 Glibenclamide only

100

−16.1 ± 14.4

0.011

−10.0 ± 4.7

<0.01

−21.7 ± 10.5

<0.01

 GLP-1 glibenclamide

100

−13.5 ± 9.7

<0.01

−0.8 ± 9.0

0.82

−14.9 ± 9.2

<0.01

Ejection fraction

 Control

100

−18.3 ± 14.1

0.01

−13.8 ± 15.5

0.03

−31.1 ± 16.0

<0.001

 GLP-1 only

100

−17.9 ± 13.3

0.01

−8.4 ± 12.7

0.10

−11.7 ± 17.8

0.10

 Glibenclamide only

100

−17.2 ± 13.4

0.01

−12.7 ± 19.6

0.14

−26.9 ± 14.2

<0.001

 GLP-1 glibenclamide

100

−16.9 ± 13.8

0.01

−8.4 ± 4.8

<0.01

−13.1 ± 9.5

<0.01

Stroke volume

 Control

100

−19.6 ± 18.1

0.03

−16.4 ± 16.3

0.02

−31.2 ± 16.6

<0.001

 GLP-1 only

100

−19.8 ± 17.5

0.01

−5.8 ± 27.1

0.56

−12.6 ± 28.8

0.26

 Glibenclamide only

100

−16.8 ± 17.8

0.08

−12.6 ± 18.2

0.12

−23.2 ± 22.1

0.04

 GLP-1 glibenclamide

100

−14.8 ± 11.1

0.01

−0.2 ± 7.3

0.96

−5.6 ± 4.4

0.03

dP/dtmin

 Control

100

−25.1 ± 14.7

<0.01

−10.9 ± 4.7

<0.001

−33.3 ± 8.6

<0.001

 GLP-1 only

100

−21.3 ± 8.3

<0.001

+5.0 ± 11.6

0.26

−21.3 ± 8.7

0.04

 Glibenclamide only

100

−26.4 ± 14.3

<0.001

−7.1 ± 12.5

0.17

−28.6 ± 13.1

<0.001

 GLP-1 glibenclamide

100

−19.6 ± 6.1

<0.001

+2.9 ± 13.0

0.55

−14.3 ± 13.6

0.02

Tau

 Control

100

+34.7 ± 16.9

<0.01

+12.7 ± 7.8

<0.01

+46.4 ± 15.4

<0.001

 GLP-1 only

100

+27.3 ± 11.6

<0.001

+8.0 ± 18.6

0.26

+31.0 ± 36.7

0.05

 Glibenclamide only

100

+30.5 ± 25.8

<0.01

+13.1 ± 19.9

0.14

+36.2 ± 26.3

<0.001

 GLP-1 glibenclamide

100

+31.3 ± 27.2

<0.001

+5.5 ± 10.2

0.17

32.5 ± 13.2

<0.001

  1. * p value compared to BL1 for each group