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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies

Fig. 4

Diastolic function (ΔdP/dtmin) in supply ischemia protocol. Mean ± SEM. There were no statistically significant differences between groups at BO1. At BL2, dP/dtmin for GLP-1 was significantly improved compared to control (p < 0.01) and numerically better than glibenclamide alone (p = 0.07). The difference between GLP-1 vs. control was maintained at BO2 (p = 0.01). At BL2, dP/dtmin for GLP-1 + glibenclamide was again significantly improved compared to control (p < 0.01), and numerically better than glibenclamide alone (p = 0.15). These differences persisted for BO2 (p < 0.01 and 0.06 respectively). There was no statistically significant difference between GLP-1 treated groups, nor any difference between the control and glibenclamide only groups, at any timepoint

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Cardiovascular Diabetology

ISSN: 1475-2840