Dipeptidyl peptidase-4 inhibition with linagliptin prevents western diet-induced vascular abnormalities in female mice

Table 1 Aortic stiffness in untreated western diet (WD)-fed mice compared to untreated control diet (CD) fed mice as indicated by determinations of aortic pulse wave velocity (PWV)

Pulse wave velocity	Main effect	p value	CDC [6]	CDL [8]	WDC [10]	WDL [10]
4 months PWV (m s⁻¹)	Diet	0.001	3.31 ± 0.08	3.28 ± 0.07	4.11*^† ± 0.16	3.44 ± 0.11
	Treatment	0.001
	Interaction	0.017
Heart rate (bpm)	Diet	0.036	442 ± 22	439 ± 26	397* ± 12	415 ± 5
	Treatment	0.639
	Interaction	0.496
4 months PWV (m s⁻¹ HR⁻¹ 100)	Diet	0.006	0.76 ± 0.04	0.77 ± 0.05	1.05*^† ± 0.06	0.83 ± 0.03
	Treatment	0.091
	Interaction	0.072

Also shown, is heart rate (HR) and PWV normalized to HR. Administration of linagliptin (WDL) prevented the increase in PWV observed WD-fed mice (WDC). Sample sizes are noted in parentheses. Values are mean ± SE
CDC control diet control, CDL control diet linagliptin, WDC western diet control and WDL western diet linagliptin. Post-hoc comparisons
* p < 0.05 CDC vs WDC; ^† p < 0.05 WDC vs WDL

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