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Table 2 Indices of vascular health measured bef

From: Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study

  Treatment group (TG) p value TG V1 vs V2 Healthy controls p value TG V1 vs HC p value TG V2 vs HC Standard group (SG) p value SG V1 vs V2 p value TG V1 vs SG V1
V1 (Pre metformin) V2 (Post metformin) HC V1 V2
PACs per hpf 16.6 ± 8.9 28.4 ± 12.8 <0.0005* 40.3 ± 20.2 <0.0005* 0.07* 17.6 ± 12 15 ± 11 0.6 0.8
FAA per hpf 26.9 ± 21 61 ± 42 <0.0005* 67 ± 29 <0.0005* 0.15 35.9 ± 15 37 ± 16 0.9 0.1
Hill colonies per well 8.3 ± 6.8 13.8 ± 9 <0.0005* 20.57 <0.0005* 0.1* 10.4 ± 6.6 11 ± 6.2 0.8 0.5
(CECs) CD45dimCD34+CD133CD144+ per ml^ 74.4 (46.4–221) 47.6 (21.8–76.7) <0.05* 42.6 (12.7–66) 0.03* 0.7 99.8 (59.4–210.5) 119.5 (80.5–527.5) 0.5 0.7
  1. Values given as mean ± SD or ^ median (Interquartile range)
  2. PACs proangiogenic cells, FAA fibronectin adhesion assay- Adhesion of PACs, cECs circulating endothelial cells, combination of CD45dimCD34+CD133 and CD144+, TG V1 pre-treatment, TG V2 post treatment, SG V1 pre-observation, SG V2 post observation
  3. * Results after Bonferroni correction
ore and after metformin therapy