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Table 2 Indices of vascular health measured bef

From: Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study

 

Treatment group (TG)

p value TG V1 vs V2

Healthy controls

p value TG V1 vs HC

p value TG V2 vs HC

Standard group (SG)

p value SG V1 vs V2

p value TG V1 vs SG V1

V1 (Pre metformin)

V2 (Post metformin)

HC

V1

V2

PACs per hpf

16.6 ± 8.9

28.4 ± 12.8

<0.0005*

40.3 ± 20.2

<0.0005*

0.07*

17.6 ± 12

15 ± 11

0.6

0.8

FAA per hpf

26.9 ± 21

61 ± 42

<0.0005*

67 ± 29

<0.0005*

0.15

35.9 ± 15

37 ± 16

0.9

0.1

Hill colonies per well

8.3 ± 6.8

13.8 ± 9

<0.0005*

20.57

<0.0005*

0.1*

10.4 ± 6.6

11 ± 6.2

0.8

0.5

(CECs) CD45dimCD34+CD133−CD144+ per ml^

74.4 (46.4–221)

47.6 (21.8–76.7)

<0.05*

42.6 (12.7–66)

0.03*

0.7

99.8 (59.4–210.5)

119.5 (80.5–527.5)

0.5

0.7

  1. Values given as mean ± SD or ^ median (Interquartile range)
  2. PACs proangiogenic cells, FAA fibronectin adhesion assay- Adhesion of PACs, cECs circulating endothelial cells, combination of CD45dimCD34+CD133− and CD144+, TG V1 pre-treatment, TG V2 post treatment, SG V1 pre-observation, SG V2 post observation
  3. * Results after Bonferroni correction
ore and after metformin therapy
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Cardiovascular Diabetology

ISSN: 1475-2840