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Table 1 Subject’s clinical and metabolic characteristics

From: Metformin improves circulating endothelial cells and endothelial progenitor cells in type 1 diabetes: MERIT study

  TG (n = 23) p value TG V1 vs V2 HC (n = 23) p value HC vs TG V1 SG (n = 9) p value SG V1 vs V2 p value SG V1 vs TG V1
TG V1 TG V2 SG V1 SG V2
Age year 46 ± 13 46 ± 12.6 1 47.4 ± 13.6 0.8
Sex M/F n 11/12 11/12 5/4
DOD years 23 ± 13.6 23.7 ± 14.1 0.9
BMI kg/m2 28.7 (24-32) 29 (23-32)  >0.05 26.2 ± 4.7 0.1 23.8 (22–27) 23.7 (21.3–27.1) 0.3 <0.05
Systolic BP mmHg 125 ± 10.8 121 ± 14 0.2 119.4 ± 9 0.2 132.8 ± 6.2 130.8 ± 12.1 0.7 0.05
Diastolic BP mmHg 76.2 ± 9.2 74 ± 7 0.1 75.7 ± 9 0.9 77 ± 8.2 72.9 ± 3.6 0.4 0.8
HbA1c mmol/mol 56.9 ± 10.5 55.9 ± 8.5 0.5 34.8 ± 2.9 <0.0001 58.6 ± 7.4 59 ± 9 0.7 0.6
HbA1c  % 7.3 ± 0.9 7.3 ± 0.8 0.6 5.3 ± 0.3 <0.0001 7.5 ± 0.70 7.5 ± 0.8 0.6  
Insulin dose units 44 (20–69) 39 (18–66) <0.001 52.3 ± 11 52.9 ± 11 0.5 0.4
Smoking y/e/n 4/2/17 0/0/23   2/1/6
Total cholesterol mmol/l 4.5 ± 0.8 4.4 ± 1 0.2 4.96 ± 0.8 0.1 4.8 ± 1.3 4.9 ± 1.4 0.8 0.7
Triglyceride mmol/l 0.9 ± 0.4 0.9 ± 0.4 0.9 1.5 ± 0.9 0.008 0.7 ± 0.32 0.7 ± 0.3 0.6 0.2
HDL-cholesterol mmol/l 1.8 ± 0.5 1.6 ± 0.4 <0.05 1.6 ± 0.4 0.1 1.9 ± 0.6 2.1 ± 0.6 0.4 0.5
Creatinine umol/l 73 (68–94) 70 (63–77) 0.01 78 (70–87) 0.3 75 (65–87) 77 (62.8–83.5) 0.7 0.7
WCC 6.4 ± 2.4 6.3 ± 2 0.7 6.3 ± 1.6 0.9 5.8 ± 1.5 5.6 ± 1.7 0.9 0.5
  1. Values are given as mean ± SD or * median [Interquartile range (IQ)]
  2. kg kilogram, BMI body mass index, BP blood pressure, M male, F female, DOD duration of diabetes, Y yes, E ex-smoker, N no, TG V1 Pre-treatment, TG V2 Post treatment, SG V1 Pre-observation, SG V2 Post observation, WCC White cell count