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Table 1 Summary of competition binding assay using M-IR

From: Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

Insulin

IR affinity IC50 (nmol/L)

P value vs. Ins

Ins

0.83 ± 0.07

–

IGlaM1

2.15 ± 0.61

0.2350

IDeg

19.59 ± 1.10

<0.0001

  1. Data represent mean ± SEM. All insulins were tested in at least four independent experiments on different days. Binding values within a single experiment were obtained in quadruplicates per insulin and averaged for each experiment
  2. Ins Regular insulin; IGlaM1 active metabolite of glargine; IDeg insulin degludec
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Cardiovascular Diabetology

ISSN: 1475-2840