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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Effect of the long-acting insulin analogues glargine and degludec on cardiomyocyte cell signalling and function

Fig. 6

Anti-apoptotic potency of long-acting insulin analogues in the presence of H2O2. H9c2 cardiomyocytes overexpressing the human insulin receptor (H9c2-E2 cells) were treated for 2 h with 100 nM of insulin and insulin analogues in the presence or absence of 800 µM H2O2 to evaluate the cardio protective effects of insulin and its analogues. Caspase 3/7 activity was measured using the promega caspase 3/7 Glo Assay. Each condition was performed in quadruplicates. Data represent mean values ± SEM, n = 5–6, *p < 0.05 vs. basal. Regular insulin Ins, insulin glargine IGla, active metabolite of insulin glargine IGlaM1, insulin degludec IDeg

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