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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice

Fig. 6

Metformin improved the impaired BM-EPCs by activating AMPK/eNOS pathway in diabetic mice. BM-EPCs from anesthetized mice were isolated and cultured. AMPK and eNOS in BM-EPCs, and intracellular NO levels were measured. Metformin significantly increased AMPK (a, b) and eNOS (c, d) phosphorylated-to-total ratio, and enhanced NO production (e, f) of BM-EPCs from diabetic mice. **P < 0.01, *P < 0.05 vs Control; # P < 0.05 vs STZ. Values are mean ± SEM (a, b, c, d: n = 4 per group; e, f: n = 6 per group)

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